Citation: Sun Hongshun, Zhou Jin, Li Yulong, Jiang Hong, Zhang Yan, Wang Jianqiang, Guo Cheng, Shen Linjiang. Design, Synthesis and Evaluation of Novel Gd-Based 1, 4, 7, 10-Tetraazacyclododecan-N, N', N, N'-tetraacetic Acid-Hydrazide Derived Contrast Agents for Magnetic Resonance Imaging[J]. Chinese Journal of Organic Chemistry, ;2019, 39(3): 778-785. doi: 10.6023/cjoc201808005 shu

Design, Synthesis and Evaluation of Novel Gd-Based 1, 4, 7, 10-Tetraazacyclododecan-N, N', N, N'-tetraacetic Acid-Hydrazide Derived Contrast Agents for Magnetic Resonance Imaging

Sun Hongshun ^a,b,, ,
Zhou Jin ^a,b ,
Li Yulong ^a ,
Jiang Hong ^a ,
Zhang Yan ^c ,
Wang Jianqiang ^b ,
Guo Cheng ^b ,
Shen Linjiang ^b,d

a.
Targeted Magnetic Resonance Imaging Contrast Agents Laboratory of Jiangsu Province, Nanjing Polytechnic Institute, Nanjing 210048
b.
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816
c.
College of Textiles and Clothing, Yancheng Vocational Institute of Industry Technology, Yancheng 224005
d.
School of Physical and Mathematical Sciences, Nanjing Tech University, Nanjing 211816

Corresponding author: Sun Hongshun, njutshs@126.com
Received Date: 7 August 2018
Revised Date: 30 September 2018
Available Online: 26 March 2018
Fund Project: the Natural Science Foundation of the Jiangsu Higher Education Institutions 17KJB320001the Natural Science Foundation of Jiangsu Province BK20181486Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20181486), the Natural Science Foundation of the Jiangsu Higher Education Institutions (Nos. 17KJB320001, 16KJB540006), the Overseas Training Program for Excellent Young Teachers and Principals of Jiangsu Province and the Qing Lan Project of Jiangsu Provincethe Natural Science Foundation of the Jiangsu Higher Education Institutions 16KJB540006

Figures(5)

Magnetic resonance imaging (MRI) is widely used in diagnostic medicine and soft tissue imaging. Contrast agents (CAs) can improve the specificity of MRI enhancement. Herein, the design, synthesis and characterization of twelve novel Gd-based 1, 4, 7, 10-tetraazacyclododecan-N, N', N, N'-tetraacetic acid (DOTA) -hydrazide derived contrast agents for MRI were reported. Among of them, 5d, 5h and 5l exhibit higher longitudinal relaxivities than the clinical Gd-DOTA at 0.5 T. The relaxivities r₁ of 5d, 5h and 5l are 4.67, 4.85 and 5.33 L·mmol^-1·s^-1 respectively. In vivo liver-target MRI shows that the potential of complex 5d was used as a novel liver-target contrast agent for MRI.
- magnetic resonance imaging (MRI),
- contrast agents,
- liver-target,
- DOTA-hydrazide,
- gadolinium,
- synthesis
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