Citation: Che Chuanliang, Hu Yimin, Ding Shanshan, Xiao Yumei, Li Jiqia, Qin Zhaohai. Design, Synthesis and Inhibition Activity of Seed Germination of Novel Pyrabactin Analogs[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 419-426. doi: 10.6023/cjoc201807057 shu

Design, Synthesis and Inhibition Activity of Seed Germination of Novel Pyrabactin Analogs

College of Science, China Agricultural University, Beijing 100193

Corresponding author: Qin Zhaohai, qinzhaohai@263.net
Received Date: 31 July 2018
Revised Date: 25 August 2018
Available Online: 12 February 2018
Fund Project: Project supported by the National Natural Science Foundation of China No. 21572265Project supported by the National Natural Science Foundation of China (No. 21572265)

Figures(3)

In order to develop more stable abscisic acid (ABA) analogs, a novel type of sulfonamide compounds was designed based on the similar synthesis strategy using pyrabactin and 2', 3'-benzo-iso-ABA (iso-PhABA) as precursors. Using 1-tetralone as raw material, 13 novel sulfonamides were synthesized by methylation, benzylic oxidation, hydrazone formation and sulfonamidation, and the reaction conditions of sulfonamidation were explored and optimized. The results of seed germination experiments showed that the target compounds exhibited different inhibition activities at a concentration of 50 μmol·L^-1, and the inhibition rates of five compounds on Arabidopsis and lettuce seeds germination were greater than 50% and 40%, respectively. These results have important reference significance for the creation of new abscisic acid synthetic phytohormones.
- pyrabactin analogs,
- sulfonamide,
- abscisic acid analogs,
- inhibition of seed germination,
- similar synthesis
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