Citation: Yue Huilan, Bao Pengli, Wang Leilei, Lü Xiaoxia, Yang Daoshan, Wang Hua, Wei Wei. Direct Synthesis Sulfonamides from Nitroarenes and Sulfonyl Chlorides in Water[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 463-468. doi: 10.6023/cjoc201807033 shu

Direct Synthesis Sulfonamides from Nitroarenes and Sulfonyl Chlorides in Water

Yue Huilan ^a ,
Bao Pengli ^b ,
Wang Leilei ^b ,
Lü Xiaoxia ^b ,
Yang Daoshan ^b ,
Wang Hua ^b ,
Wei Wei ^a,b,,

a.
Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai 810008
b.
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165

Corresponding author: Wei Wei, weiweiqfnu@163.com
Received Date: 21 July 2018
Revised Date: 31 August 2018
Available Online: 17 February 2018
Fund Project: the National Natural Science Foundation of China 21302110the International Cooperation Project of Qinghai Province 2017-HZ-806Project supported by the International Cooperation Project of Qinghai Province (Nos. 2018-HZ-806, 2017-HZ-806), the Qinghai Key Laboratory of Tibetan Medicine Research (No. 2017-ZJ-Y11), the Natural Science Foundation of Shandong Province (Nos. ZR2018MB009, ZR2016JL012), and the National Natural Science Foundation of China (Nos. 21302109, 21302110, 21601106)the National Natural Science Foundation of China 21601106the Qinghai Key Laboratory of Tibetan Medicine Research 2017-ZJ-Y11the National Natural Science Foundation of China 21302109the Natural Science Foundation of Shandong Province ZR2016JL012the Natural Science Foundation of Shandong Province ZR2018MB009the International Cooperation Project of Qinghai Province 2018-HZ-806

Figures(3)

A simple and practical route for construction of various sulfonamides from nitroarenes and sulfonyl chlorides with iron powder as the sole reductant in water (green solvent) under open-air conditions was developed. The protocol features low-cost, environmentally benign solvent, mild reaction conditions and wide broad substrate scope.
- water,
- green organic synthesis,
- sulfonamides,
- sulfonyl chlorides,
- iron power
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