Citation: Zhao Hui, Zhu Xiaoyun, Hu Xiaoxia, Liu Yan'gea, Tang Chunlei, Feng Bainian. N-Alkylation of N-H Compounds in N, N-Dimethylformamide Dialkyl Acetal[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 434-442. doi: 10.6023/cjoc201807010 shu

N-Alkylation of N-H Compounds in N, N-Dimethylformamide Dialkyl Acetal

Zhao Hui ^a,† ,
Zhu Xiaoyun ^b,† ,
Hu Xiaoxia ^a,† ,
Liu Yan'gea ^a ,
Tang Chunlei ^a,, ,
Feng Bainian ^a,,

a.
School of Pharmaceutical Science, Jiangnan University, Wuxi 214122
b.
Changzhou Runnuo Biotechnology Co., LTD., Changzhou 213022

Corresponding author: Tang Chunlei, tangcl@jiangnan.edu.cn Feng Bainian, fengbainian@jiangnan.edu.cn

^†

Received Date: 4 July 2018
Revised Date: 4 September 2018
Available Online: 26 February 2018
Fund Project: Project supported by the National First-Class Discipline Program of Food Science and Technology (No.JUFSTR20180101) and the Jiangsu Province Policy Guidance Special Fund (No.BZ2016021)the Jiangsu Province Policy Guidance Special Fund BZ2016021the National First-Class Discipline Program of Food Science and Technology JUFSTR20180101

Figures(1)

The N, N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds. The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N, N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N, N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated.
- N, N-dimethylformamide dialkyl acetal,
- nitrogen alkylation,
- synthesis
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