Citation: Cheng Huicheng, Lin Jinlong, Zhang Yaofeng, Chen Bing, Wang Min, Cheng Lihua, Ma Jiaoli. Recent Advances in Transition-Metal-Catalyzed Directing Group Assisted Nitration of Inert C-H Bonds[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 318-327. doi: 10.6023/cjoc201807002 shu

Recent Advances in Transition-Metal-Catalyzed Directing Group Assisted Nitration of Inert C-H Bonds

Cheng Huicheng ^a,b ,
Lin Jinlong ^a ,
Zhang Yaofeng ^a ,
Chen Bing ^a ,
Wang Min ^a ,
Cheng Lihua ^a,b ,
Ma Jiaoli ^a,b,,

a.
College of Chemcal Engineering, Guangdong University of Petrochemical Technology, Maoming 525000
b.
Guangdong Province Petrochemical Corrosion and Safety Engineering Technology Research and Development Center, Maoming 525000

Corresponding author: Ma Jiaoli, xiaojiaoli.good@163.com
Received Date: 1 July 2018
Revised Date: 29 August 2018
Available Online: 26 February 2018
Fund Project: Project supported by the Maoming City Technology Bureau (No. 917313), the Guangdong University of Petrochemical Technology (Nos. 517152、517136、201711656024)

Figures(6)

Aromatic nitro compounds are of great importance as chemical raw materials and organic synthesis intermediates. Traditional electrophilic nitration is difficult to achieve regioselective nitrification. In recent years, transition-metal-catalyzed C-H bond activation has developed rapidly. Most functional groups can be introduced into specific sites of aromatics through the chelation of transition metals with directing groups. Directing-group assisted C-H nitration, which is catalyzed by palladium, rhodium, ruthenium and other transition-metal, has made important progress due to its less byproducts, good regioselectivity and environmental protection. According to different transition metal catalysts, the research progress on transition-metal-catalyzed directing-group assisted C-H nitration is summarized, and the limitations of the research field and prospects for future develop-ment are presented.
- transition metal-catalyzed,
- inert C-H bonds,
- nitration,
- aromatic nitro compounds
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