Citation: Yuan Shuo, Wang Sixi, Chen Jinjie, Zhao Longfei, Yu Bin, Liu Hongmin. Aniline-Promoted Synthesis of Isobenzofuranone Derivatives[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 3009-3015. doi: 10.6023/cjoc201806035 shu

Aniline-Promoted Synthesis of Isobenzofuranone Derivatives

Yuan Shuo ^a,b,c ,
Wang Sixi ^a ,
Chen Jinjie ^a ,
Zhao Longfei ^a,b,c ,
Yu Bin ^a,b,c,d,, ,
Liu Hongmin ^a,b,c,,

a.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001
b.
Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001
c.
Key Laboratory of Technology of Drug Preparation, Ministry of Education, Zhengzhou 450001
d.
Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou 510033

Corresponding author: Yu Bin, zzuyubin@hotmail.com Liu Hongmin, liuhm@zzu.edu.cn
Received Date: 21 June 2018
Revised Date: 16 July 2018
Available Online: 24 November 2018
Fund Project: the Undergraduate Innovation and Entrepreneurship Training Program of Zhengzhou University 201810459101the National Natural Science Foundation of China 81773562the Key Research Program of Higher Education of Henan Province 18B350009the National Natural Science Foundation of China 81703326the National Key Research Program of Proteins 2016YFA0501800the China Postdoctoral Science Foundation 2018M630840the Open Project of Guangdong Provincial Key Laboratory of New Drug Screening GDKLNDS-2018OF006Project supported by the National Natural Science Foundation of China (Nos. 81430085, 81773562, 81703326), the National Key Research Program of Proteins (No. 2016YFA0501800), the Scientific Program of Henan Province (No. 182102310123), the China Postdoctoral Science Foundation (No. 2018M630840), the Open Project of Guangdong Provincial Key Laboratory of New Drug Screening (No. GDKLNDS-2018OF006), the Key Research Program of Higher Education of Henan Province (No. 18B350009), and the Undergraduate Innovation and Entrepreneurship Training Program of Zhengzhou University (No. 201810459101)the National Natural Science Foundation of China 81430085the Scientific Program of Henan Province 182102310123

Figures(3)

Isobenzofuranone derivatives are widely found in nature and have shown diverse biological activities. In this work, the aniline-promoted synthesis of isobenzofuranone derivatives starting from 2-carboxybenzaldehyde and substituted acetophenones under mild reaction conditions is reported. This method has broad substrate scope, high yields, and is operationally convenient, and therefore could serve as an attractive strategy for practical synthesis of isobenzofuranone derivatives.
- isobenzofuranone derivatives,
- aniline,
- cascade reactions
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