Citation: Meng Fankang, Lou Chunbo. Research Progress in Biocontainment of Genetically Modified Organisms[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2231-2242. doi: 10.6023/cjoc201806018 shu

Research Progress in Biocontainment of Genetically Modified Organisms

Meng Fankang ^a,b ,
Lou Chunbo ^a,b,,

a.
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101
b.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100149

Corresponding author: Lou Chunbo, louchunbo@im.ac.cn
Received Date: 13 June 2018
Revised Date: 8 August 2018
Available Online: 22 September 2018
Fund Project: Ministry of Science and Technology of the People's Republic of China 2015CB910300Project supported by the National Natural Science Foundation of China 31722002Project supported by the National Natural Science Foundation of China 31470818Project supported by the National Natural Science Foundation of China (Nos. 31470818, 31722002) and Ministry of Science and Technology of the People's Republic of China (No. 2015CB910300)

Figures(6)

With the rapid progress of synthetic biology and other related filed, there is a continuous growth of the applications of genetically modified organisms in many aspects, including industry, agriculture, health and environment. However, unintended release or uncontrolled propagation of these genetically modified organisms may cause significant side effects to the nature ecological environment. In order to eradicate the escaping problem and horizontal gene transfer between artificial and natural organisms, many researches have been focused on how to limit genetically modified organisms to a controlled environment. The research progress of biocontainment of genetically modified organisms mainly from three aspects of traditional biocontainment strategies, the orthogonalization of central dogma and the design of complex genetic networks is highlighted. It is believed that the advanced biocontainment technology would promote the further application of synthetic biology.
- synthetic biology,
- genetically modified organisms,
- biosafety,
- orthogonal central dogma,
- genetic network
1. [1]
  Zhang, H. M.; Lou, C. Sci. Soc. 2014, 4, 26(in Chinese).
2. [2]
  (a) Khalil, A. S.; Collins, J. J. Nat. Rev. Genet. 2010, 11, 367.
  (b) Lee, J. W.; Na, D.; Park, J. M.; Lee, J.; Choi, S.; Lee, S. Y. Nat. Chem. Biol. 2012, 8, 536.
  (c) Cameron, D. E.; Bashor, C. J.; Collins, J. J. Nat. Rev. Microbiol. 2014, 12, 381.
3. [3]
  Redford, K. H.; Adams, W.; Mace, G. M. PLoS Biol. 2013, 11, e1001530. doi: 10.1371/journal.pbio.1001530
4. [4]
  Alphey, L.; Alphey, N. PLoS Pathog. 2014, 10, e1003909. doi: 10.1371/journal.ppat.1003909
5. [5]
  (a) Carmichael, R. E.; Boyce, A.; Matthewman, C.; Patron, N. J. New Phytol. 2015, 208, 20.
  (b) Patron, N. J.; Orzaez, D.; Marillonnet, S.; Warzecha, H.; Matthewman, C.; Youles, M.; Raitskin, O.; Leveau, A.; Farre, G.; Rogers, C.; Smith, A.; Hibberd, J.; Webb, A. A.; Locke, J.; Schornack, S.; Ajioka, J.; Baulcombe, D. C.; Zipfel, C.; Kamoun, S.; Jones, J. D.; Kuhn, H.; Robatzek, S.; Van Esse, H. P.; Sanders, D.; Oldroyd, G.; Martin, C.; Field, R.; O'Connor, S.; Fox, S.; Wulff, B.; Miller, B.; Breakspear, A.; Radhakrishnan, G.; Delaux, P. M.; Loque, D.; Granell, A.; Tissier, A.; Shih, P.; Brutnell, T. P.; Quick, W. P.; Rischer, H.; Fraser, P. D.; Aharoni, A.; Raines, C.; South, P. F.; Ane, J. M.; Hamberger, B. R.; Langdale, J.; Stougaard, J.; Bouwmeester, H.; Udvardi, M.; Murray, J. A.; Ntoukakis, V.; Schafer, P.; Denby, K.; Edwards, K. J.; Osbourn, A.; Haseloff, J. New Phytol. 2015, 208, 13.
6. [6]
  Zhang, Y.; Chen, J.; Cui, X.; Luo, D.; Xia, H.; Dai, J.; Zhu, Z.; Hu, W. Sci. Rep. 2015, 5, 7614. doi: 10.1038/srep07614
7. [7]
  (a) Alphey, L. Annu. Rev. Entomol. 2014, 59, 205.
  (b) Gantz, V. M.; Jasinskiene, N.; Tatarenkova, O.; Fazekas, A.; Macias, V. M.; Bier, E.; James, A. A. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, E6736.
  (c) Harris, A. F.; Nimmo, D.; McKemey, A. R.; Kelly, N.; Scaife, S.; Donnelly, C. A.; Beech, C.; Petrie, W. D.; Alphey, L. Nat. Biotechnol. 2011, 29, 1034.
  (d) Hammond, A.; Galizi, R.; Kyrou, K.; Simoni, A.; Siniscalchi, C.; Katsanos, D.; Gribble, M.; Baker, D.; Marois, E.; Russell, S.; Burt, A.; Windbichler, N.; Crisanti, A.; Nolan, T. Nat. Biotechnol. 2016, 34, 78.
  (e) Lacroix, R.; McKemey, A. R.; Raduan, N.; Kwee Wee, L.; Hong Ming, W.; Guat Ney, T.; Rahidah, A. A. S.; Salman, S.; Subramaniam, S.; Nordin, O.; Hanum, A. T. N.; Angamuthu, C.; Marlina Mansor, S.; Lees, R. S.; Naish, N.; Scaife, S.; Gray, P.; Labbe, G.; Beech, C.; Nimmo, D.; Alphey, L.; Vasan, S. S.; Han Lim, L.; Wasi, A. N.; Murad, S. PLoS One 2012, 7, e42771.
8. [8]
  (a) Rovner, A. J.; Haimovich, A. D.; Katz, S. R.; Li, Z.; Grome, M. W.; Gassaway, B. M.; Amiram, M.; Patel, J. R.; Gallagher, R. R.; Rinehart, J.; Isaacs, F. J. Nature 2015, 527.
  (b) Mandell, D. J.; Lajoie, M. J.; Mee, M. T.; Takeuchi, R.; Kuznetsov, G.; Norville, J. E.; Gregg, C. J.; Stoddard, B. L.; Church, G. M. Nature 2015, 518, 55.
  (c) Lajoie, M. J.; Rovner, A. J.; Goodman, D. B.; Aerni, H. R.; Haimovich, A. D.; Kuznetsov, G.; Mercer, J. A.; Wang, H. H.; Carr, P. A.; Mosberg, J. A.; Rohland, N.; Schultz, P. G.; Jacobson, J. M.; Rinehart, J.; Church, G. M.; Isaacs, F. J. Science 2013, 342, 357.
9. [9]
  (a) Marlière, P.; Patrouix, J.; Döring, V.; Herdewijn, P.; Tricot, S.; Cruveiller, S.; Bouzon, M.; Mutzel, R. Angew. Chem., Int. Ed. 2011, 50, 7109.
  (b) Pezo, V.; Liu, F. W.; Abramov, M.; Froeyen, M.; Herdewijn, P.; Marliere, P. Angew. Chem., Int. Ed. 2013, 52, 8139.
  (c) Malyshev, D. A.; Dhami, K.; Lavergne, T.; Chen, T.; Dai, N.; Foster, J. M.; Corrêa, I. R.; Romesberg, F. E. Nature 2014, 509, 385.
  (d) Malyshev, D. A.; Dhami, K.; Lavergne, T.; Chen, T.; Dai, N.; Foster, J. M.; Correa, I. R., Jr.; Romesberg, F. E. Nature 2014, 509, 385.
10. [10]
  (a) de Lorenzo, V. In Handbook of Hydrocarbon and Lipid Microbiologyed, Springer, Berlin, Heidelberg, 2010, p. 2435.
  (b) Solé, R. V.; Montañez, R.; Duran-Nebreda, S. Biology Direct 2015, 10, 37.
11. [11]
  Landrain, T.; Meyer, M.; Perez, A. M.; Sussan, R. Syst. Synth. Biol. 2013, 7, 115. doi: 10.1007/s11693-013-9116-4
12. [12]
  Berg, P.; Baltimore, D.; Brenner, S.; Roblin, R. O.; Singer, M. F. Science 1975, 188, 991. doi: 10.1126/science.1056638
13. [13]
  Dana, G. V.; Kuiken, T.; Rejeski, D.; Snow, A. A. Nature 2012, 483, 29. doi: 10.1038/483029a
14. [14]
  Wilson, D. J. Acc. Res. 1993, 3, 177. doi: 10.1080/08989629308573848
15. [15]
  (a) Wang, Z.; Xu, W.; Liu, L.; Zhu, T. F. Nat. Chem. 2016, 8, 698;
  (b) Steidler, L.; Neirynck, S.; Huyghebaert, N.; Snoeck, V.; Ver- meire, A.; Goddeeris, B.; Cox, E.; Remon, J. P.; Remaut, E. Nat. Biotechnol. 2003, 21, 785;
  (c) Cohen, S. S.; Barner, H. D. J. Biol. Chem. 1957, 226, 631.
16. [16]
  Curtiss, R.; Inoue, M.; Pereira, D.; Hsu, J. C.; Alexander, L.; Rock, L. In Molecular of Cloning of Recombinant DNA, Elsevier, Amsterdam, Netherlands, 1977, p. 99.
17. [17]
  Steidler, L.; Neirynck, S.; Huyghebaert, N.; Snoeck, V.; Vermeire, A.; Goddeeris, B.; Cox, E.; Remon, J. P.; Remaut, E. Nat. Biotechnol. 2003, 21, 785. doi: 10.1038/nbt840
18. [18]
  Nguyen, L. V.; Cox, K. M.; Ke, J. S.; Peele, C. G.; Dickey, L. F. Transgenic Res. 2012, 21, 1071. doi: 10.1007/s11248-012-9594-2
19. [19]
  Hirota, R.; Abe, K.; Katsuura, Z.; Noguchi, R.; Moribe, S.; Motomura, K.; Ishida, T.; Alexandrov, M.; Funabashi, H.; Ikeda, T.; Kuroda, A. Sci. Rep.-Uk 2017, 7.
20. [20]
  Molin, S.; Klemm, P.; Poulsen, L. K.; Biehl, H.; Gerdes, K.; Andersson, P. Bio-Technology 1987, 5, 1315.
21. [21]
  Contreras, A.; Molin, S.; Ramos, J. L. Appl. Environ. Microb. 1991, 57, 1504.
22. [22]
  Szafranski, P.; Mello, C. M.; Sano, T.; Smith, C. L.; Kaplan, D. L.; Cantor, C. R. Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 1059. doi: 10.1073/pnas.94.4.1059
23. [23]
  Ronchel, M. C.; Ramos, J. L. Appl. Environ. Microbiol. 2001, 67, 2649. doi: 10.1128/AEM.67.6.2649-2656.2001
24. [24]
  Oliver, M. J.; Quisenberry, J. E.; Trolinder, N. L. G.; Keim, D. L. Google Patents 1998.
25. [25]
  Heuer, H.; Smalla, K. Environ. Biosaf. Res. 2007, 6, 3. doi: 10.1051/ebr:2007034
26. [26]
  Lyon, D. Y.; Monier, J. M.; Dupraz, S.; Freissinet, C.; Simonet, P.; Vogel, T. M. Astrobiology 2010, 10, 285. doi: 10.1089/ast.2009.0359
27. [27]
  Torres, B.; Jaenecke, S.; Timmis, K. N.; Garcia, J. L.; Diaz, E. Environ. Microbiol. 2000, 2, 555. doi: 10.1046/j.1462-2920.2000.00138.x
28. [28]
  Caliando, B. J.; Voigt, C. A. Nat. Commun. 2015, 6.
29. [29]
  Wright, O.; Delmans, M.; Stan, G.-B.; Ellis, T. ACS Synth. Biol. 2014, 4, 307.
30. [30]
  Schmidt, M.; de Lorenzo, V. FEBS Lett. 2012, 586, 2199. doi: 10.1016/j.febslet.2012.02.022
31. [31]
  Liu, C. C.; Schultz, P. G. Annu. Rev. Biochem. 2010, 79, 413. doi: 10.1146/annurev.biochem.052308.105824
32. [32]
  Wang, L.; Brock, A.; Herberich, B.; Schultz, P. G. Science 2001, 292, 498. doi: 10.1126/science.1060077
33. [33]
  Chin, J. W.; Cropp, T. A.; Anderson, J. C.; Mukherji, M.; Zhang, Z. W.; Schultz, P. G. Science 2003, 301, 964. doi: 10.1126/science.1084772
34. [34]
  Wang, H. H.; Isaacs, F. J.; Carr, P. A.; Sun, Z. Z.; Xu, G.; Forest, C. R.; Church, G. M. Nature 2009, 460, 894. doi: 10.1038/nature08187
35. [35]
  Isaacs, F. J.; Carr, P. A.; Wang, H. H.; Lajoie, M. J.; Sterling, B.; Kraal, L.; Tolonen, A. C.; Gianoulis, T. A.; Goodman, D. B.; Reppas, N. B.; Emig, C. J.; Bang, D.; Hwang, S. J.; Jewett, M. C.; Jacobson, J. M.; Church, G. M. Science 2011, 333, 348. doi: 10.1126/science.1205822
36. [36]
  Ostrov, N.; Landon, M.; Guell, M.; Kuznetsov, G.; Teramoto, J.; Cervantes, N.; Zhou, M.; Singh, K.; Napolitano, M. G.; Moos-burner, M.; Shrock, E.; Pruitt, B. W.; Conway, N.; Goodman, D. B.; Gardner, C. L.; Tyree, G.; Gonzales, A.; Wanner, B. L.; Norville, J. E.; Lajoie, M. J.; Church, G. M. Science 2016, 353, 819. doi: 10.1126/science.aaf3639
37. [37]
  (a) Wang, K.; Schmied, W. H.; Chin, J. W. Angew. Chem., Int. Ed. 2012, 51, 2288;
  (b) Niu, W.; Schultz, P. G.; Guo, J. ACS Chem. Biol. 2013, 8, 1640;
  (c) Anderson, J. C.; Wu, N.; Santoro, S. W.; Lakshman, V.; King, D. S.; Schultz, P. G. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 7566.
38. [38]
  Tack, D. S.; Ellefson, J. W.; Thyer, R.; Wang, B.; Gollihar, J.; Forster, M. T.; Ellington, A. D. Nat. Chem. Biol. 2016, 12, 138. doi: 10.1038/nchembio.2002
39. [39]
  Wang, N. X.; Li, Y.; Niu, W.; Sun, M.; Cerny, R.; Li, Q. S.; Guo, J. T. Angew. Chem., Int. Ed. 2014, 53, 4867. doi: 10.1002/anie.201402092
40. [40]
  Si, L. L.; Xu, H.; Zhou, X. Y.; Zhang, Z. W.; Tian, Z. Y.; Wang, Y.; Wu, Y. M.; Zhang, B.; Niu, Z. L.; Zhang, C. L.; Fu, G.; Xiao, S. L.; Xia, Q.; Zhang, L. H.; Zhou, D. M. Science 2016, 354, 1170. doi: 10.1126/science.aah5869
41. [41]
  Kimoto, M.; Kawai, R.; Mitsui, T.; Yokoyama, S.; Hirao, I. Nucleic Acids Res. 2009, 37.
42. [42]
  Yang, Z. Y.; Hutter, D.; Sheng, P. P.; Sismour, A. M.; Benner, S. A. Nucleic Acids Res. 2006, 34, 6095. doi: 10.1093/nar/gkl633
43. [43]
  Yang, Z. Y.; Chen, F.; Alvarado, J. B.; Benner, S. A. J. Am. Chem. Soc. 2011, 133, 15105. doi: 10.1021/ja204910n
44. [44]
  Kim, H. J.; Leal, N. A.; Hoshika, S.; Benner, S. A. J. Org. Chem. 2014, 79, 3194. doi: 10.1021/jo402665d
45. [45]
  Leconte, A. M.; Hwang, G. T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F. E. J. Am. Chem. Soc. 2008, 130, 2336. doi: 10.1021/ja078223d
46. [46]
  Seo, Y. J.; Hwang, G. T.; Ordoukhanian, P.; Romesberg, F. E. J. Am. Chem. Soc. 2009, 131, 14596. doi: 10.1021/ja907027a
47. [47]
  Malyshev, D. A.; Dhami, K.; Lavergne, T.; Chen, T. J.; Dai, N.; Foster, J. M.; Correa, I. R.; Romesberg, F. E. Nature 2014, 509, 385. doi: 10.1038/nature13314
48. [48]
  Zhang, Y.; Ptacin, J. L.; Fischer, E. C.; Aerni, H. R.; Caffaro, C. E.; Jose, K. S.; Feldman, A. W.; Turner, C. R.; Romesberg, F. E. Nature 2017, 551, 644. doi: 10.1038/nature24659
49. [49]
  Zhang, Y.; Lamb, B. M.; Feldman, A. W.; Zhou, A. X.; Lavergne, T.; Li, L.; Romesberg, F. E. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 1317. doi: 10.1073/pnas.1616443114
50. [50]
  Lopez, G.; Anderson, J. C. ACS Synth. Biol. 2015, 4, 1279. doi: 10.1021/acssynbio.5b00085
51. [51]
  Ravikumar, A.; Arrieta, A.; Liu, C. C. Nat. Chem. Biol. 2014, 10, 175. doi: 10.1038/nchembio.1439
52. [52]
  Basu, R. S.; Murakami, K. S., In Nucleic Acid Polymerasesed, Springer, Berlin, Heidelberg, 2014, p. 237.
53. [53]
  Rackham, O.; Chin, J. W. Nat. Chem. Biol. 2005, 1, 159. doi: 10.1038/nchembio719
54. [54]
  Chubiz, L. M.; Rao, C. V. Nucleic Acids Res. 2008, 36, 4038. doi: 10.1093/nar/gkn354
55. [55]
  An, W.; Chin, J. W. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 8477. doi: 10.1073/pnas.0900267106
56. [56]
  Orelle, C.; Carlson, E. D.; Szal, T.; Florin, T.; Jewett, M. C.; Mankin, A. S. Nature 2015, 524, 119. doi: 10.1038/nature14862
57. [57]
  Jia, B.; Qi, H.; Li, B. Z.; Pan, S.; Liu, D.; Liu, H.; Cai, Y.; Yuan, Y. J. ACS Synth. Biol. 2017, 6, 2108. doi: 10.1021/acssynbio.7b00148
58. [58]
  Wang, Z.; Xu, W.; Liu, L.; Zhu, T. F. Nat. Chem. 2016, 8, 698. doi: 10.1038/nchem.2517
59. [59]
  Knudsen, S. M.; Karlstrom, O. H. Appl. Environ. Microb. 1991, 57, 85.
60. [60]
  Bej, A. K.; Perlin, M. H.; Atlas, R. M. Appl. Environ. Microbiol. 1988, 54, 2472.
61. [61]
  Chan, C. T.; Lee, J. W.; Cameron, D. E.; Bashor, C. J.; Collins, J. J. Nat. Chem. Biol. 2016, 12, 82. doi: 10.1038/nchembio.1979
62. [62]
  Gallagher, R. R.; Patel, J. R.; Interiano, A. L.; Rovner, A. J.; Isaacs, F. J. Nucl. Acids Res. 2015, 43, 1945. doi: 10.1093/nar/gku1378
63. [63]
  Cai, Y.; Agmon, N.; Choi, W. J.; Ubide, A.; Stracquadanio, G.; Caravelli, K.; Hao, H.; Bader, J. S.; Boeke, J. D. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 1803. doi: 10.1073/pnas.1424704112
64. [64]
  Schmidt, M.; Pei, L. Toxicol. Sci. 2010, 120, S204.
1. [1]
  Yang Liu , Peng Chen , Lei Liu . Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook. University Chemistry, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085
2. [2]
  Tianyu Feng , Guifang Jia , Peng Zou , Jun Huang , Zhanxia Lü , Zhen Gao , Chu Wang . Construction of the Chemistry Biology Experiment Course in the Chemistry “101 Program”. University Chemistry, 2024, 39(10): 69-77. doi: 10.12461/PKU.DXHX202409002
3. [3]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
4. [4]
  Ying Zhang , Fang Ge , Zhimin Luo . AI-Driven Biochemical Teaching Research: Predicting the Functional Effects of Gene Mutations. University Chemistry, 2025, 40(3): 277-284. doi: 10.12461/PKU.DXHX202412104
5. [5]
  . . Chinese Journal of Inorganic Chemistry, 2024, 40(12): 0-0.
6. [6]
  Yonghui ZHOU , Rujun HUANG , Dongchao YAO , Aiwei ZHANG , Yuhang SUN , Zhujun CHEN , Baisong ZHU , Youxuan ZHENG . Synthesis and photoelectric properties of fluorescence materials with electron donor-acceptor structures based on quinoxaline and pyridinopyrazine, carbazole, and diphenylamine derivatives. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 701-712. doi: 10.11862/CJIC.20230373
7. [7]
  Wei HE , Jing XI , Tianpei HE , Na CHEN , Quan YUAN . Application of solar-driven inorganic semiconductor-microbe hybrids in carbon dioxide fixation and biomanufacturing. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 35-44. doi: 10.11862/CJIC.20240364
8. [8]
  Zhongyan Cao , Shengnan Jin , Yuxia Wang , Yiyi Chen , Xianqiang Kong , Yuanqing Xu . Advances in Highly Selective Reactions Involving Phenol Derivatives as Aryl Radical Precursors. University Chemistry, 2025, 40(4): 245-252. doi: 10.12461/PKU.DXHX202405186
9. [9]
  Yurong Tang , Yunren Shi , Yi Xu , Bo Qin , Yanqin Xu , Yunfei Cai . Innovative Experiment and Course Transformation Practice of Visible-Light-Mediated Photocatalytic Synthesis of Isoquinolinone. University Chemistry, 2024, 39(5): 296-306. doi: 10.3866/PKU.DXHX202311087
10. [10]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
11. [11]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
12. [12]
  Jianfeng Yan , Yating Xiao , Xin Zuo , Caixia Lin , Yaofeng Yuan . Comprehensive Chemistry Experimental Design of Ferrocenylphenyl Derivatives. University Chemistry, 2024, 39(4): 329-337. doi: 10.3866/PKU.DXHX202310005
13. [13]
  Zhibei Qu , Changxin Wang , Lei Li , Jiaze Li , Jun Zhang . Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles. University Chemistry, 2024, 39(7): 278-286. doi: 10.3866/PKU.DXHX202311039
14. [14]
  Dan Li , Hui Xin , Xiaofeng Yi . Comprehensive Experimental Design on Ni-based Catalyst for Biofuel Production. University Chemistry, 2024, 39(8): 204-211. doi: 10.3866/PKU.DXHX202312046
15. [15]
  Zhaoxin LI , Ruibo WEI , Min ZHANG , Zefeng WANG , Jing ZHENG , Jianbo LIU . Advancements in the construction of inorganic protocells and their cell mimic and bio-catalytical applications. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2286-2302. doi: 10.11862/CJIC.20240235
16. [16]
  Jinghan ZHANG , Guanying CHEN . Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249
17. [17]
  Lina Feng , Guoyu Jiang , Xiaoxia Jian , Jianguo Wang . Application of Organic Radical Materials in Biomedicine. University Chemistry, 2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171
18. [18]
  Dongxia Zhang , Sijia Hao , Jiarui Wang , Jiwei Wang , Xiaogang Dong , Liang Jiao . Construction and Reflection on the Safety Management of Hazardous Chemicals in University Laboratories. University Chemistry, 2024, 39(10): 229-235. doi: 10.12461/PKU.DXHX202403078
19. [19]
  Qiying Xia , Guokui Liu , Yunzhi Li , Yaoyao Wei , Xia Leng , Guangli Zhou , Aixiang Wang , Congcong Mi , Dengxue Ma . Construction and Practice of “Teaching-Learning-Assessment Integration” Model Based on Outcome Orientation: Taking “Structural Chemistry” as an Example. University Chemistry, 2024, 39(10): 361-368. doi: 10.3866/PKU.DXHX202311007
20. [20]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128

Get Citation

PDF

XML

Metrics

PDF Downloads(67)
Abstract views(2600)
HTML views(585)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142