Citation: Zhang Jingxing, Yao Tingting, Liu Jing, Li Huayue, Li Wenli. Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 328-338. doi: 10.6023/cjoc201806003 shu

Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway

Zhang Jingxing ^a ,
Yao Tingting ^a ,
Liu Jing ^a ,
Li Huayue ^a,b ,
Li Wenli ^a,b,,

a.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003
b.
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237

Corresponding author: Li Wenli, liwenli@ouc.edu.cn
Received Date: 1 June 2018
Revised Date: 10 September 2018
Available Online: 17 February 2018
Fund Project: the National Natural Science Foundation of China 81561148012the National Natural Science Foundation of China 31171201the National Natural Science Foundation of China 31570032Project supported by the National Natural Science Foundation of China (Nos. 31171201, 81561148012, 31570032)

Figures(10)

Diketopiperazines (DKPs) are derivatives of cyclodipeptides resulted from the condensation of two α-amino acids. The conformationally constrained six-membered ring makes DKP an attractive pharmacophore in medicinal chemistry, exhibiting a wide range of bioactivities. Recently, there has been increased interests in synthesizing DKPs and biosynthesis is an effective pathway to broaden their structural diversity. Different from non-ribosomal peptide synthetases (NRPSs)-dependent pathways, cyclodipeptide synthases (CDPSs) use aminoacyl-tRNAs (aa-tRNAs) as substrates and the resulting cyclodipeptides are further modified by associated tailoring enzymes to yield the final products. To date, six CDPS-dependent pathways for synthesizing DKPs compounds have been reported. A brief overview of recent progresses on CDPS-dependent DKPs biosynthetic pathway is provided.
- diketopiperazines,
- non-ribosomal peptide synthetases,
- cyclodipeptide synthases,
- biosynthetic pathway
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