Citation: Shi Lei, Xu Jingjing, Bi Jingjing, Zhang Zhiguo, Liu Tongxin, Yang Xiaolan, Zhang Guisheng. Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 3016-3025. doi: 10.6023/cjoc201805038 shu

Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds

Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Corresponding author: Zhang Guisheng, zgs@htu.cn
Received Date: 17 May 2018
Revised Date: 5 June 2018
Available Online: 16 November 2018
Fund Project: the Key Scientific Research Project of Henan Provinc 18A150009the Henan Normal University Science Foundation for Young Scholars 2016QK10the National Natural Science Foundation of China 21702051Project supported by the National Natural Science Foundation of China (Nos. 21605039, 21702051), the Key Scientific Research Project of Henan Provinc (Nos. 18A150009, 17A350006), the Henan Normal University Science Foundation for Young Scholars (No. 2016QK10)the National Natural Science Foundation of China 21605039the Key Scientific Research Project of Henan Provinc 17A350006

Figures(2)

Quinoline derivatives, aryl hydrazines and hydrazide compounds have significant biological activities. Benzo[h] quinoline derivatives were synthesized from 1-naphthylamine, substituted benzaldehyde and methyl pyruvate by Doebner-Miller reaction. After the ester was reduced, the corresponding aldehyde was obtained by oxidation. Benzo[h] quinolinium and quinoline hydrazide compounds were synthesized by reacting benzo[h] quinoline formaldehyde with hydrazine salts and hydrazides, respectively. The preliminary activity data showed that most of the compounds exhibited significant inhibitory activities against cycle protein 25B (CDC 25B) and protein tyrosine phosphatase PTP 1B.
- Benzo[h]quinoline derivatives,
- hydrazone,
- hydrazide,
- CDC 25B,
- PTP 1B,
- inhibitory activity
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