Citation: Zhang Yong, Yang hongzhen, Yu Xinling, Cheng Xu, Li Weijian, Guo Lingmei, Hai Li, Guo Li, Wu Yong. Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes[J]. Chinese Journal of Organic Chemistry, ;2018, 38(12): 3211-3218. doi: 10.6023/cjoc201805022 shu

Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes

Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041

Corresponding author: Guo Li, guoli@scu.edu.cn Wu Yong, wyong@scu.edu.cn
Received Date: 9 May 2018
Revised Date: 31 July 2018
Available Online: 5 December 2018
Fund Project: the National Natural Science Foundation of China 81573286Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286, 81602954)the National Natural Science Foundation of China 81602954the National Natural Science Foundation of China 81373259

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Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(Ⅲ)-catalyzed nitrogen atom directed C-H activation is described. The reaction proceeds smoothly at room temperature and generates the corresponding products in moderate to excellent yields. Meanwhile, it has a broad substrate scope and opens up an attractive avenue for the application of direct hydroxymethylation in the synthesis of biologically active compounds.
- C-H activation,
- paraformaldehyde,
- hydroxymethylation,
- room temperature
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