Citation: Wang Xiang, Chen Ping, Zhi Sanjun, Hu Huayou, Kan Yuhe. CBr₄-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 3123-3126. doi: 10.6023/cjoc201804037 shu

CBr₄-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles

Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai'an 223300

Corresponding author: Wang Xiang, hurricanwx@163.com
Received Date: 18 April 2018
Revised Date: 13 June 2018
Available Online: 29 November 2018
Fund Project: the National Natural Science Foundation of China 51403073Project supported by the National Natural Science Foundation of China (No. 51403073), the Department of Education of Jiangsu Province (No. 16KJB150006) and the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials (No. JSKC15145)the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials JSKC15145the Department of Education of Jiangsu Province 16KJB150006

Figures(1)

2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitrile derivatives not only exhibit a variety of important biological activities, but also are important intermediates in organic synthesis. The CBr₄-promoted reaction of aromatic aldehydes with 2-(1H-benzo[d] imidazol-2-yl) acetonitrile to obtain 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles was developed. Structurally diverse 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles were obtained in moderate to good yields (74%~96%) under mild conditions. This method has the advantages of operational simplicity and wide substrate scope.
- benzimidazol,
- carbon tetrabromide,
- acrylonitrile,
- Knoevenagel condensation
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通讯作者: 陈斌, bchen63@163.com

CBr₄-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles