Citation: Zhang Zhirui, Kan Jinglan, Feng Huaming, Liu Qingyun, Tao Zhu, Xiao Xin. Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 1972-1976. doi: 10.6023/cjoc201804008 shu

Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

a.
Department of Pediatric, The Ninth People's Hospital of Chongqing, Chongqing 400700
b.
College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014
c.
Key Laboratory of Macrocyclic and Supramolecular Chenmistry of Guizhou Province, Guiyang 550025
d.
College of Chemistry and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590

Corresponding author: Xiao Xin, gyhxxiaoxin@163.com
Received Date: 4 April 2018
Revised Date: 17 May 2018
Available Online: 5 August 2018
Fund Project: the Science and Technology Fund of Guizhou Province 2016-1030the Innovation Program for High-Level Talents of Guizhou Province 2016-5657the Major Program for Creative Research Groups of Guizhou Provincial Education Department 2017-028Project supported by the Science and Technology Fund of Guizhou Province (No. 2016-1030), the Innovation Program for High-Level Talents of Guizhou Province (No. 2016-5657) and the Major Program for Creative Research Groups of Guizhou Provincial Education Department (No. 2017-028)

Figures(5)

A novel supramolecular host-guest complex of the anticancer drug capecitabine (CAP) with symmetrical α, α', δ, δ'-tetramethyl-cucurbit^[6]uril (TMeQ[6]) has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetryand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research ﬁelds.
- supramolecular,
- host-guest,
- cucurbit[n]uril,
- capecitabine,
- self-assembly
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