Citation: Xu Linlin, Xu Hui, Lin Haixia, Dai Huixiong. Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 1940-1948. doi: 10.6023/cjoc201804004 shu

Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

Xu Linlin ^a ,
Xu Hui ^c ,
Lin Haixia ^a,, ,
Dai Huixiong ^b,,

a.
Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444
b.
bDepartment of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203
c.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Lin Haixia, haixialin@staff.shu.edu.cn Dai Huixiong, xdai@sioc.ac.cn
Received Date: 2 April 2018
Revised Date: 23 April 2018
Available Online: 3 August 2018
Fund Project: the National Natural Science Foundation of China 21772211Project supported by the National Natural Science Foundation of China (No. 21772211) and the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2014229)the Youth Innovation Promotion Association of Chinese Academy of Sciences 2014229

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Primary anilines are widely used in pharmaceutical, agrochemicals and material chemistry. In recent years, the green and efficient methods for constructing carbon-nitrogen (C-N) bonds to introduce primary amines has been one of the hottest topics in chemical synthesis. The direct C-H primary amination of aromatic compounds have received considerable attention due to its high efficiency and practicality. The recent progress in the C-H primary amination of aromatic compounds reactions is reviewed. Furthermore, the synthetic challenge and prospect in the future development for the synthesis of primary anilines through direct C-H amination are summarized.
- amination,
- C-H bond functionalization,
- primary anilines,
- transition-metal catalyzed
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