Citation: Ren Linjing, Ran Maogang, Fang Xuehong, Zhao Ling, Yao Qiuli. An Efficient Synthesis of 1-Arylvinylphosphonates via Direct Functionalization of C (sp³)—H Bond[J]. Chinese Journal of Organic Chemistry, ;2018, 38(10): 2791-2797. doi: 10.6023/cjoc201803016 shu

An Efficient Synthesis of 1-Arylvinylphosphonates via Direct Functionalization of C (sp³)—H Bond

School of Pharmacy, Zunyi Medical University, Zunyi 56300

Corresponding author: Yao Qiuli, yao.qiuli@zmc.edu.cn
Received Date: 13 March 2018
Revised Date: 5 May 2018
Available Online: 1 October 2018
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21462056, 21801261), the Science and Technology Foundation of Guizhou Province (No. [2014]7542) and the Zunyi Medical University (Nos. 20163715, F-627)the Zunyi Medical University 20163715the National Natural Science Foundation of China 21462056the National Natural Science Foundation of China 21801261the Science and Technology Foundation of Guizhou Province [2014]7542the Zunyi Medical University F-627

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The direct functionalization of the C (sp³)—H bond adjacent to the phosphonate group for the preparation of vinyl phosphonates was rarely developed. Herein, a simple and efficient tetrabutylammonium iodide catalyzed protocol for the preparation of vinyl phosphonates from benzylic phosphonates and paraformaldehyde is achieved under mild conditions in air. Moderate to high yields can be obtained for a broad scope of substrates.
- phosphonate,
- olefination,
- C(sp³)—H functionalization,
- Horner-Wadsworth-Emmons reaction
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

An Efficient Synthesis of 1-Arylvinylphosphonates via Direct Functionalization of C (sp3)—H Bond

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通讯作者: 陈斌, bchen63@163.com

An Efficient Synthesis of 1-Arylvinylphosphonates via Direct Functionalization of C (sp³)—H Bond