Citation: Zhang Wei, Yao Zijian, Deng Wei. Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery[J]. Chinese Journal of Organic Chemistry, ;2018, 38(10): 2713-2719. doi: 10.6023/cjoc201803006 shu

Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

Zhang Wei ^a ,
Yao Zijian ^a ,
Deng Wei ^a,b,,

a.
School of Materials Science and Engineering, Shanghai University, Shanghai 200444
b.
School of Chemical and Engineering, Shanghai Institute of Technology, Shanghai 201418

Corresponding author: Deng Wei, wdeng@shu.edu.cn
Received Date: 5 March 2018
Revised Date: 30 May 2018
Available Online: 15 October 2018
Fund Project: Project supported by the Key Subject of Shanghai Municipal Education Commission (No. J50704) and the Natural Science Foundation of Shanghai City (No. 16ZR1435700)the Natural Science Foundation of Shanghai City 16ZR1435700the Key Subject of Shanghai Municipal Education Commission J50704

Figures(6)

Poly (amido amine)s with diverse topographical structures are promising candidates for gene delivery and drug carriers. A series of poly (amido amine)s (PAAs) with the same repeating units, however, different degree of branching, were successfully prepared by Michael addition polycondensation of N, N-methylenebis (acrylamide) (MBA) and L-cysteine methyl ester hydrochloride (CYS) in a water/dimethyl sulfoxide co-solvent. The obtained disposed cationic PAAs exhibit good DNA condensation capacities.
- poly(amido amine)s,
- branched polymer,
- gene delivery,
- L-cysteine methyl ester hydrochloride,
- cyclodextrin
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