Citation: Lu Yue, Jiang Guofang, Xie Zongbo, Chen Guoqing, Le Zhanggao. Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1837-1841. doi: 10.6023/cjoc201801047 shu

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Jiang Guofang, zbxie@ecit.cn Le Zhanggao, zhgle@ecit.cn
Received Date: 30 January 2018
Revised Date: 17 March 2018
Available Online: 4 July 2018
Fund Project: the Science and Technology Foundation of the Jiangxi Provincial Education Department GJJ150584the Science and Technology Foundation of the Jiangxi Provincial Education Department KJLD14050the National Natural Science Foundation of China 21462001Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21262002, 21465002), the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006), the Science and Technology Foundation of the Jiangxi Provincial Education Department (Nos. KJLD14050, GJJ150584)the National Natural Science Foundation of China 21465002the Science and Technology Projects of Jiangxi Province 20161BCB24006the National Natural Science Foundation of China 21262002

A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2, 5-dihydroxy-1, 4-dithiane using amano lipase M from Mucor javanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.
- α-active methylene nitrile,
- 2, 5-dihydroxy-1, 4-dithiane,
- lipase,
- Gewald reaction,
- 2-aminothiophene
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