Citation: Sun Hongshun, Li Yulong, Jiang Hong, Guo Cheng, Shen Linjiang. Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1779-1785. doi: 10.6023/cjoc201801044 shu

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

Sun Hongshun ^a,b ,
Li Yulong ^b ,
Jiang Hong ^b ,
Guo Cheng ^a ,
Shen Linjiang ^a,c,,

a.
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816
b.
Targeted MRI Contrast Agents Laboratory of Jiangsu Province, Nanjing Polytechnic Institute, Nanjing 210048
c.
School of Physical and Mathematical Sciences, Nanjing Tech University, Nanjing 211816

Corresponding author: Shen Linjiang, ljshen@njtech.edu.cn
Received Date: 29 January 2018
Revised Date: 4 March 2018
Available Online: 29 July 2018
Fund Project: Project supported by the Natural Science Foundation in Jiangsu Province (No. 17KJB320001), the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (No. PPZY2015B179), the Training Program of Students Innovation and Entrepreneurship in Jiangsu Province (No. 201712920001Y), and the Qing Lan Project of Jiangsu Provincethe Training Program of Students Innovation and Entrepreneurship in Jiangsu Province 201712920001Ythe Top-notch Academic Programs Project of Jiangsu Higher Education Institutions PPZY2015B179the Natural Science Foundation in Jiangsu Province 17KJB320001

Figures(3)

Magnetic resonance imaging (MRI) is widely used in diagnostic medicine and soft tissue imaging. Contrast agents (CAs) can improve the specificity of MRI enhancement. Herein, the design, synthesis and relaxivity of two novel binuclear nonionic Gd-based DOTA-hydrazide derived MRI contrast agents, (Gd-DOTAH)₂-DYMB and (Gd-DOTAH)₂-DYMBP are reported. They have improved longitudinal relaxivity values of 11.4 and 11.7 L·mmol^-1·s^-1 per molecule or 5.7 and 5.9 L·mmol^-1·Gd^-1·s^-1 at 0.5 T, respectively, which are higher than that of the mononuclear clinical macrocyclic agent Gd-DOTA. And in vitro MRI studies suggest the potential of these two agents as MRI contrast agents in improving the diagnostic sensitivity and accuracy.
- magnetic resonance imaging (MRI),
- contrast agents,
- synthesis,
- relaxivity,
- DOTA-hydrazide,
- Gd-DOTA
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