Advanced Search

Home

Citation: Liu Qinglong, Chen Ahong, Jiang Zhihua, Ma Yanlei, Tang Jinying, Xu Wei, Liu Yanping, Fu Yanhui. A New Indole Alkaloid from the Stems and Leaves of Nauclea officinalis[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1833-1836. doi: 10.6023/cjoc201801042 shu

A New Indole Alkaloid from the Stems and Leaves of Nauclea officinalis

Liu Qinglong ^a,b,c ,
Chen Ahong ^a,b,c ,
Jiang Zhihua ^a,b,c ,
Ma Yanlei ^a,b,c ,
Tang Jinying ^a,b,c ,
Xu Wei ^c ,
Liu Yanping ^a,b,, ,
Fu Yanhui ^a,b,c,,

a.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158
b.
Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158
c.
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122

Corresponding author: Liu Yanping, liuyanpinghs@163.com Fu Yanhui, fuyanhui80@163.com
Received Date: 28 January 2018
Revised Date: 17 March 2018
Available Online: 4 July 2018
Fund Project: Project supported by the Applied Technology Research and Development and Demonstration Project of Hainan Province (No. ZDXM2015063), the National Natural Science Foundation of China (Nos. 21662011 and 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19)the Applied Technology Research and Development and Demonstration Project of Hainan Province ZDXM2015063the National Natural Science Foundation of China 31660097the National Natural Science Foundation of China 21662011the Program for Innovative Research Team in University IRT-16R19

Figures(2)

A new indole alkaloid, nauclofficine (1), together with three known alkaloids, naucleamide A (2), naucleamide D (3) and latifoliamide A (4), were isolated from the stems and leaves of Nauclea officinalis. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from N. officinalis for the first time. The cytotoxicities of compounds 1~4 were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Research results showed that compounds 1~4 exhibited significant inhibitory effects with IC₅₀ values comparable to those of cisplatin.
- Nauclea,
- Nauclea officinalis,
- nauclofficine,
- cytotoxicities
1. [1]
  Haudecoeur, R.; Peuchmaur, M.; Pérès, B.; Rome, M.; Taïwe, G. S.; Boumendjel, A.; Boucherle, B. J. Ethnopharmacol. 2018, 212, 106. doi: 10.1016/j.jep.2017.10.011
2. [2]
  Sichaem, J.; Surapinit, S.; Siripong, P.; Khumkratok, S.; Jong-ara-mruang, J.; Tip-pyang, S. Fitoterapia 2010, 81, 830. doi: 10.1016/j.fitote.2010.05.004
3. [3]
  Sun, J.; Lou, H.; Dai, S.; Xu, H.; Zhao, F.; Liu, K. Phytochemistry 2008, 69, 1405. doi: 10.1016/j.phytochem.2008.01.008
4. [4]
  Li, N.; Cao, L.; Cheng, Y.; Meng, Z. Q.; Tang, Z. H.; Liu, W. J.; Wang, Z. Z.; Ding, G.; Xiao, W. Pharm. Biol. 2014, 52, 1445. doi: 10.3109/13880209.2014.895910
5. [5]
  Flora Reipublicae Popularis Sinicae Editorial Board Flora Reipublicae Popularis Sinicae, Vol. 71(1), Science Press, Beijing, 1999, p. 260 (in Chinese).
6. [6]
  Shigemori, H.; Kagata, T.; Ishiyama, H.; Morah, F.; Ohsaki, A.; Kobayashi, J. I. Chem. Pharm. Bull. 2003, 51, 58. doi: 10.1248/cpb.51.58
7. [7]
  Agomuoh, A. A.; Ata, A.; Udenigwe, C. C.; Aluko, R. E.; Irenus, I. Chem. Biodiversity 2013, 10, 401. doi: 10.1002/cbdv.v10.3
8. [8]
  Fu, Y. H.; Di, Y. T.; He, H. P.; Li, S. L.; Zhang, Y.; Hao, X. J. J. Nat. Prod. 2014, 77, 57. doi: 10.1021/np4005823
9. [9]
  Ma, Y. L.; Liu, Y. P.; Zhang, C.; Zhao, W. H.; Shi, S.; He, D. N.; Zhang, P.; Liu, X. H.; Han T. T.; Fu, Y. H. Bioorg. Chem. 2018, 76, 359. doi: 10.1016/j.bioorg.2017.12.016
1. [1]
  Pengli GUAN , Renhu BAI , Xiuling SUN , Bin LIU . Trianiline-derived aggregation-induced emission luminogen probe for lipase detection and cell imaging. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1817-1826. doi: 10.11862/CJIC.20250058
2. [2]
  Xiaofeng Zhu , Bingbing Xiao , Jiaxin Su , Shuai Wang , Qingran Zhang , Jun Wang . Transition Metal Oxides/Chalcogenides for Electrochemical Oxygen Reduction into Hydrogen Peroxides. Acta Physico-Chimica Sinica, 2024, 40(12): 2407005-0. doi: 10.3866/PKU.WHXB202407005
3. [3]
  Gaofeng Zeng , Shuyu Liu , Manle Jiang , Yu Wang , Ping Xu , Lei Wang . Micro/Nanorobots for Pollution Detection and Toxic Removal. University Chemistry, 2024, 39(9): 229-234. doi: 10.12461/PKU.DXHX202311055
4. [4]
  Zhaoxin LI , Ruibo WEI , Min ZHANG , Zefeng WANG , Jing ZHENG , Jianbo LIU . Advancements in the construction of inorganic protocells and their cell mimic and bio-catalytical applications. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2286-2302. doi: 10.11862/CJIC.20240235
5. [5]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
6. [6]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
7. [7]
  Shipeng WANG , Shangyu XIE , Luxian LIANG , Xuehong WANG , Jie WEI , Deqiang WANG . Piezoelectric effect of Mn, Bi co-doped sodium niobate for promoting cell proliferation and bacteriostasis. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1919-1931. doi: 10.11862/CJIC.20240094
8. [8]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
9. [9]
  Jiahao Zeng , Hui Chao . 诱导程序性细胞死亡的金属抗肿瘤药物研究. University Chemistry, 2025, 40(6): 145-159. doi: 10.12461/PKU.DXHX202406019
10. [10]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
11. [11]
  Quanliang Chen , Zhaohui Zhou . Research on the Active Site of Nitrogenase over Fifty Years. University Chemistry, 2024, 39(7): 287-293. doi: 10.3866/PKU.DXHX202310133
12. [12]
  Xinyu ZENG , Guhua TANG , Jianming OUYANG . Inhibitory effect of Desmodium styracifolium polysaccharides with different content of carboxyl groups on the growth, aggregation and cell adhesion of calcium oxalate crystals. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1563-1576. doi: 10.11862/CJIC.20230374
13. [13]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423
14. [14]
  Tiejin Chen , Xiaokuang Xue , Jian Li , Minhui Cui , Yongliang Hao , Mianqi Xue , Haihua Xiao , Jiechao Ge , Pengfei Wang . Membrane-anchoring nanoengineered carbon dots as a pyroptosis amplifier for robust tumor photodynamic-immunotherapy. Acta Physico-Chimica Sinica, 2025, 41(10): 100113-0. doi: 10.1016/j.actphy.2025.100113
15. [15]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
16. [16]
  Yukai Jiang , Yihan Wang , Yunkai Zhang , Yunping Wei , Ying Ma , Na Du . Characterization and Phase Diagram of Surfactant Lyotropic Liquid Crystal. University Chemistry, 2024, 39(4): 114-118. doi: 10.3866/PKU.DXHX202309033
17. [17]
  Jiayu Gu , Siqi Wang , Jun Ling . Kinetics of Living Copolymerization: A Brief Discussion. University Chemistry, 2025, 40(4): 100-107. doi: 10.12461/PKU.DXHX202406012
18. [18]
  Zhiyang Li , Hui Deng , Xinqi Cai , Zhuo Chen . Magnetic Core/Shell-Capsules Locally Neutralize Gastric Acid for Efficient Delivery of Active Probiotics. Acta Physico-Chimica Sinica, 2024, 40(7): 2306051-0. doi: 10.3866/PKU.WHXB202306051
19. [19]
  Ruiqin Feng , Ye Fan , Yun Fang , Yongmei Xia . Strategy for Regulating Surface Protrusion of Gold Nanoflowers and Their Surface-Enhanced Raman Scattering. Acta Physico-Chimica Sinica, 2024, 40(4): 2304020-0. doi: 10.3866/PKU.WHXB202304020
20. [20]
  Congqi Zhu , Bo Liu , Ruchun Li . Dual active sites enhancing alkaline H₂-production performance. Acta Physico-Chimica Sinica, 2025, 41(11): 100146-0. doi: 10.1016/j.actphy.2025.100146

Metrics

PDF Downloads(8)
Abstract views(1101)
HTML views(167)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

Powered By info@rhhz.net

/

DownLoad: Full-Size Img PowerPoint