Citation: Li Zhejian, Gao Bao, Huang Hanmin. Amidation of Acid Chlorides to Primary Amides with Ammonium Salts[J]. Chinese Journal of Organic Chemistry, ;2018, 38(6): 1431-1436. doi: 10.6023/cjoc201801034 shu

Amidation of Acid Chlorides to Primary Amides with Ammonium Salts

a.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
b.
Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei 230026

Corresponding author: Huang Hanmin, hanmin@ustc.edu.cn
Received Date: 24 January 2018
Revised Date: 6 March 2018
Available Online: 8 June 2018
Fund Project: the Anhui Provincial Natural Science Foundation 1708085MB28the National Natural Science Foundation of China 21702197Project supported by the National Natural Science Foundation of China (Nos. 21672199, 21702197), the CAS Interdisciplinary Innovation Team, the Fundamental Research Funds for the Central Universities and the Anhui Provincial Natural Science Foundation (No. 1708085MB28)the National Natural Science Foundation of China 21672199

Figures(1)

A practical amidation reaction for the synthesis of primary amides is presented, in which the simple NH₄Cl was identified as a practical and convenient amine source. A series of aromatic and aliphatic acid chlorides were successfully compatible with this protocol, affording the corresponding amides in good to excellent yields, which provides a rapid and reliable approach to amides from simple starting materials. Introducing the appropriate N-methyl pyrrolidone (NMP) into the system as solvent and acid-binding reagent plays a key role to avoid the use of stoichiometric amounts of base.
- ammonium salts,
- amidation,
- primary amides,
- acid chlorides,
- N-methyl pyrrolidone
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1.
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