Citation: Liu Lili, Huang Danfeng, Wang Yuxiang, Wen Lan, Yang Zheng, Su Yingpeng, Wang Kehu, Hu Yulai. A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines[J]. Chinese Journal of Organic Chemistry, ;2018, 38(6): 1469-1476. doi: 10.6023/cjoc201712036 shu

A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huangdf@nwnu.edu.cn Hu Yulai, huyl@nwnu.edu.cn
Received Date: 26 December 2017
Revised Date: 2 February 2018
Available Online: 11 June 2018
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21462037)the National Natural Science Foundation of China 21462037the National Natural Science Foundation of China 21662030

Figures(2)

A Lewis acid-catalyzed[3+2] cycloaddition of trifluoromethylated N-acylhydrazones with alkenes was explored, and a series of CF₃-substituted pryazolidines were obtained in high yields (up to 91%). The reaction features the use of cheap and readily available trifluoromethylated N-acylhydrazones as trifluoromethyl building blocks, mild reaction conditions and easy operation. Furthermore, the cycloadducts can be transformed into trifluoromethylated pyrazolines in excellent yields.
- trifluoromethyl building blocks,
- cycloaddition,
- trifluoromethylated N-acylhydrazones,
- alkenes,
- trifluoromethyl pyrazolidines,
- trifluoromethyl pyrazolines
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A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines