Citation: Gao Yunpeng, Wang Jianbo. Continuous Flow Reaction of Diazo Compounds[J]. Chinese Journal of Organic Chemistry, ;2018, 38(6): 1275-1291. doi: 10.6023/cjoc201712029 shu

Continuous Flow Reaction of Diazo Compounds

Gao Yunpeng ^a ,
Wang Jianbo ^a,b,,

a.
Beijing National Laboratory of Molecular Sciences(BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871
b.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Wang Jianbo, wangjb@pku.edu.cn
Received Date: 20 December 2017
Revised Date: 22 January 2018
Available Online: 6 June 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21332002) and the National Basic Research Program of China (973 Program, No. 2015CB856600)the National Basic Research Program of China 973 Programthe National Natural Science Foundation of China 21332002the National Basic Research Program of China 2015CB856600

Figures(31)

Diazo compounds are versatile building blocks in organic synthesis. They are served as 1, 3-dipoles, nucleophiles and carbene precursors in the construction of various organic molecules. However, the utility of diazo compounds is significantly limited by toxicity, instability and explosive potential. The application of continuous flow technology in this field could ensure the safety of these reactions. It also provides the possibility to utilize diazo compounds in a large scale. Categorized by the types of diazo compounds, the application of continuous flow technology in transformations of diazo compounds is systematically reviewed in this paper.
- diazo compound,
- flow chemistry,
- microreactor,
- organic synthesis
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