Citation: Xue Hong, Dong Yu, Feng Lei, Li Haibo, Li Jin, Zhang Zhiwei. Research Progress in the Synthesis of 3-Indolecarboxylates[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1029-1034. doi: 10.6023/cjoc201712010 shu

Research Progress in the Synthesis of 3-Indolecarboxylates

College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018

Corresponding author: Zhang Zhiwei, zhangzw@hebust.edu.cn
Received Date: 6 December 2017
Revised Date: 6 January 2018
Available Online: 18 May 2018
Fund Project: the Natural Science Foundation of Hebei Province B2016208124Project supported by the National Natural Science Foundation of China (No. 21302039) and the Natural Science Foundation of Hebei Province (No.B2016208124)the National Natural Science Foundation of China 21302039

Figures(8)

Indole derivatives have been considered as "privileged scaffolds" in drug discovery since they are capable of binding many receptors with high affinity. 3-Indolecarboxylates are widespread structure motifs in many natural products and drug molecules, such as arbidol, tropisetron, PD 0298029, and grandilodine A, etc. Consequently, synthetic studies toward 3-indolecarboxylates have been reported in recent years. Elegant cyclization strategies have been developed via transition-metal catalyzed or transition-metal-free reactions, and direct functionalization at C-3 position for synthesis of ester functional groups was also extremely attractive. Based on our studies toward synthesis of 3-indolecarboxylates, the recent developments of synthesis of 3-indolecarboxylates by different synthetic methods in view of the types of substrates are reviewed.
- 3-indolecarboxylate,
- metal-catalyzed cyclization,
- C—H functionalization,
- transition metal-free reaction,
- recent development
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