Citation: Zhong Shuaishuai, Huang Peng, Wang Xingyue, Lin Mi, Ge Chunhua. Synthesis of Quinoline-2, 4-diones from Cyanoacetanilide Derivatives[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1199-1206. doi: 10.6023/cjoc201711011 shu

Synthesis of Quinoline-2, 4-diones from Cyanoacetanilide Derivatives

College of Chemistry, Liaoning University, Shenyang 110036

Corresponding author: Huang Peng, huangp019@126.com Ge Chunhua, chhge@lnu.edu.cn
Received Date: 7 November 2017
Revised Date: 25 December 2017
Available Online: 10 May 2018
Fund Project: the Doctoral Scientific Research Foundation of Liaoning Province 201601096Project supported by the Doctoral Scientific Research Foundation of Liaoning Province (No. 201601096) and the Science and Technology Plan Project of Shenyang City (No. F17-231-1-05)the Science and Technology Plan Project of Shenyang City F17-231-1-05

Figures(3)

Quinoline-2, 4-dione unit is present in many natural products and synthetic compounds along with a broad range of bioactivities. Herein, a new approach to the synthesis of quinoline-2, 4-diones is developed based on a methyl triflate (TfOMe)-promoted intramolecular Houben-Hoesch reaction of α, α-dialkyl substituted cyanoacetanilides. The broad substrate scope, simple operation and mild reaction conditions make this synthetic method very attractive.
- quinolinone,
- nitrile,
- methylation,
- cyclization
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