Citation: Li Zhenyi, Hu Xiaoyu, Jiang Juli, Zhang Dongmei, Xiao Shoujun, Lin Chen, Wang Leyong. Recent Advances in Closed-Loop and Smart Insulin Delivery Systems[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 29-39. doi: 10.6023/cjoc201708065 shu

Recent Advances in Closed-Loop and Smart Insulin Delivery Systems

a.
School of Chemistry and Chmeical Engineering, Nanjing University, Nanjing 210023
b.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023

Corresponding author: Lin Chen, linchen@nju.edu.cn
Received Date: 31 August 2017
Revised Date: 19 September 2017
Available Online: 26 January 2017
Fund Project: the National Natural Science Foundation of China 21572101the National Natural Science Foundation of China 21672102Project supported by the National Natural Science Foundation of China (Nos. 21672102, 21572101)

Figures(6)

Insulin is a commonly prescribed drug for the treatment of type Ⅰ and type Ⅱ diabetes. As for the efficiency in controlling blood glucose level, insulin therapy is one of the most effective treatments for diabetes. The current administration route of insulin is mainly through subcutaneous injection, which leads to many undesirable side effects such as pain, local tissue necrosis or infection, and nerve damage. Recently, various closed-loop and smart insulin delivery systems have been developed based on the emerging nanotechnologies. Recent progress in the construction of closed-loop and smart insulin delivery system, which mainly focuses on the response mechanism, different strategies for fabricating the carrier matrix, and the regulation principle of the smart insulin release is described. Advantages and drawbacks of the current insulin delivery systems are also discussed, along with the opportunities and challenges in future.
- diabetes,
- insulin,
- glucose-response,
- closed-loop delivery system,
- smart drug release
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