Citation: Zhu Xinju, Niu Junlong, Zhao Xuemei, Hao Xinqi, Song Maoping. Synthesis of Chiral Bis(imidazoline) Ligands with Biphenyl Backbone and Their Application in the Asymmetric Cyclopropanation Reaction[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 118-123. doi: 10.6023/cjoc201708037 shu

Synthesis of Chiral Bis(imidazoline) Ligands with Biphenyl Backbone and Their Application in the Asymmetric Cyclopropanation Reaction

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001

Corresponding author: Hao Xinqi, xqhao@zzu.edu.cn Song Maoping, mpsong@zzu.edu.cn
Received Date: 19 August 2017
Revised Date: 8 November 2017
Available Online: 17 January 2017
Fund Project: the National Natural Science Foundation of Chin 21672192the National Natural Science Foundation of Chin 21528201the China Postdoctoral Science Foundation 2016M602254Project supported by the National Natural Science Foundation of China (Nos. 21528201, 21672192) and the China Postdoctoral Science Foundation (No. 2016M602254)

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A serial of biphenyl bisimidazolines containing both axial and central chirality have been synthesized for the first time. Compared with common method, Ullmann coupling methodology exhibited superior performance expecially for t-Bu substituted ligands. The obtained ligands were further applied in the Cu-catalyzed asymmetric cyclopropanation.
- imidazoline,
- axial chirality,
- central chirality,
- asymmetric cyclopropanation
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