Citation: Yu Wenquan, Chang Junbiao. I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 215-220. doi: 10.6023/cjoc201708009 shu

I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

Yu Wenquan ,
Chang Junbiao ^,

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001

Corresponding author: Chang Junbiao, changjunbiao@zzu.edu.cn
Received Date: 6 August 2017
Revised Date: 31 August 2017
Available Online: 15 January 2017
Fund Project: Project supported by the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004) and the National Natural Science Foundation of China (No. 81330075)National Natural Science Foundation of China 81330075Outstanding Young Talent Research Fund of Zhengzhou University 1521316004

Figures(2)

A concise and efficient iodine/copper(Ⅰ) iodide-mediated intramolecular oxidative C—O bond formation reaction has been developed for oxazole synthesis. Under the optimal reaction conditions, oxidative cyclization of readily accessible enamide substrates provides facile access to a variety of oxazole derivatives bearing aryl, alkyl, amide, ester, and acyl substituents.
- iodine,
- copper(Ⅰ) iodide,
- oxidative cyclization,
- enamides,
- oxazoles
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I2/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

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I₂/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles