Citation: Dai Hong, Huang Meiling, Ge Shushan, Sun Siyu, Shen Aibao, Cheng Xiaoyan, Li Chunjian, Shi Jian. Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3289-3295. doi: 10.6023/cjoc201707024 shu

Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group

Dai Hong ^a,b ,
Huang Meiling ^b ,
Ge Shushan ^b ,
Sun Siyu ^a ,
Shen Aibao ^a,, ,
Cheng Xiaoyan ^a ,
Li Chunjian ^c ,
Shi Jian ^c,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
School of Pharmacy, Nantong University, Nantong 226001
c.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Shen Aibao, ntgao2016@163.com Shi Jian, gaohbhe2015@aliyun.com
Received Date: 21 July 2017
Revised Date: 21 August 2017
Available Online: 8 December 2017
Fund Project: the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013the Science and Technology Project Fund of Nantong City MS22015020Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (No. MS22015020)the National Natural Science Foundation of China 21372135

Figures(2)

In order to explore novel pyrazole derivatives with good biological activities, a series of pyrazole-containing pyrazole oxime esters were designed and synthesized according to the method of active substructure combination. Their structures were determined by ¹H NMR, ¹³C NMR spectra and elemental analysis. The preliminary bioactivity test showed that some of the target compounds had good insecticidal activity against Aphis medicaginis at a concentration of 500 μg/mL, some title compounds displayed good insecticidal activity against Nilaparvata lugens at 500 μg/mL. In addition, some of the designed compounds exhibited certain anti-tumor activity against HepG2 cells.
- pyrazol,
- pyrazole oxime,
- synthesis,
- bioactivity
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