Citation: Ding Huaiwei, Li Juan, Guo Qinghui, Xiao Yan. Research Progress on Transition-Metal-Catalyzed C-H Activation/C-O Coupling Reaction of Arenes[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3112-3129. doi: 10.6023/cjoc201706006 shu

Research Progress on Transition-Metal-Catalyzed C-H Activation/C-O Coupling Reaction of Arenes

Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016

Corresponding author: Xiao Yan, xiaoyan@syphu.edu.cn
Received Date: 4 June 2017
Revised Date: 28 July 2017
Available Online: 16 December 2017
Fund Project: Project supported by the Natural Science Foundation of Liaoning Province (No. 2015020745)the Natural Science Foundation of Liaoning Province 2015020745

Figures(18)

Transition metal catalyzed C-H activation/C-O coupling reaction of arenes serves as a powerful strategy for constructing phenols, aryl ethers and phenolic esters, and thus represents a hot topic in the field of organic chemistry. This strategy is effective and atom-economic as it allows people to construct C-O bond directly from arenes, avoiding pre-functionalization of arenes. Recent development on transition metal catalyzed C-H activation/C-O coupling reactions according to different species of transition metal catalysts is summarized. Possible mechanisms of typical protocols are explained and compared. Existing problems and limitations, and a brief outlook in this field is also presented.
- C-H activation,
- C-O coupling,
- phenol,
- aryl ether,
- phenolic ester
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