Citation: Hao Wenyan, Wang Yuyun, Liu Yunyun. Catalyst-Free Selective C5-H Bromination and Chlorination of 8-Amido Quinolines[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3198-3203. doi: 10.6023/cjoc201705041 shu

Catalyst-Free Selective C5-H Bromination and Chlorination of 8-Amido Quinolines

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022

Corresponding author: Hao Wenyan, wenyanhao@jxnu.edu.cn
Received Date: 28 May 2017
Revised Date: 18 July 2017
Available Online: 30 December 2017
Fund Project: the Scientific Research Fund of Jiangxi Provincial Education Department GJJ160285Project supported by the National Natural Science Foundation of China (Nos. 21562024, 21762023), and the Scientific Research Fund of Jiangxi Provincial Education Department (No. GJJ160285)the National Natural Science Foundation of China 21762023the National Natural Science Foundation of China 21562024

Figures(2)

A simple and efficient selective halogenation (Cl, Br) reaction in the C5 position of 8-amidoquinolines has been developed via catalyst free C-H bond elaboration. This facile synthetic method shows good substrate tolerance and most of the halogenated products were obtained with excellent yield.
- 8-amidoquinoline,
- selective,
- catalyst-free,
- C5-H bond,
- halogenation
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