Citation: He Bo, Wang Dawei, Yang Wenchao, Chen Qiong, Yang Guangfu. Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2895-2904. doi: 10.6023/cjoc201705031 shu

Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides

He Bo ^a ,
Wang Dawei ^b ,
Yang Wenchao ^a ,
Chen Qiong ^a ,
Yang Guangfu ^a,b,,

a.
Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079
b.
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071

Corresponding author: Yang Guangfu, gfyang@mail.ccnu.edu.cn
Received Date: 21 May 2017
Revised Date: 22 June 2017
Available Online: 4 November 2017
Fund Project: Project supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology (No. 2014BAD20B01), the National Natural Science Foundation of China (No. 21372093, 21672079) and the Chinese Universities Basic Scientific Research (No. CCNU15A02011)the Chinese Universities Basic Scientific Research CCNU15A02011the National Natural Science Foundation of China 21372093the National Natural Science Foundation of China 21672079the National Key Technology Research and Development Program of the Ministry of Science and Technology 2014BAD20B01

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4-Hydroxyphenylpyruvate dioxygenase (HPPD), a target for green herbicide discovery, has recently attracted a large number of famous scientists attention owing to controlling efficacy of resistant weeds. The structures of HPPD, inhibitors binding sites, mode of action and their metabolites are summarized. The current commercial and developing pyrazole-containing herbicides of HPPD are analyzed. Based on combining theory and practical application, a direction to find or design a new inhibitor is also oriented.
- 4-hydroxyphenylpyruvate dioxygenase,
- mode of action,
- binding site,
- herbicide
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