Citation: Wang Shoufeng, Zheng Qingfei, Duan Panpan, Liu wen. Progress in Synthesis of Thiopeptide Antibiotics Analogues[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1653-1666. doi: 10.6023/cjoc201702017 shu

Progress in Synthesis of Thiopeptide Antibiotics Analogues

Wang Shoufeng ^a,b,, ,
Zheng Qingfei ^c ,
Duan Panpan ^c ,
Liu wen ^c,,

a.
College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022
b.
Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, University of Jinan, Jinan 250022
c.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032

Corresponding author: Wang Shoufeng, chm_wangsf@ujn.edu.cn Liu wen, wliu@sioc.ac.cn
Received Date: 15 February 2017
Revised Date: 20 March 2017
Available Online: 10 July 2017
Fund Project: the Natural Science Foundation of Shandong Province ZR2016HM44the National Natural Science Foundation of China 31430005Project supported by the National Natural Science Foundation of China (No. 31430005) and the Natural Science Foundation of Shandong Province (No.ZR2016HM44)

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Thiopeptide antibiotics, which are a growing class of sulfur-rich and highly modified polyazolyl peptide natural products, have been appreciated because of their complex structures, potent biological activities and unusual modes of action. Recently, a great deal of effort has been devoted to the development of various approaches for the efficient synthesis of thiopeptide antibiotics analogues. This review summarizes synthetic approaches towards thiopeptide antibiotics analogues via semisynthesis, combinatorial biosynthesis and precursor-directed mutasynthesis.
- thiopeptide antibiotics analogue,
- semisynthesis,
- combinatorial biosynthesis,
- precursor-directed mutasynthesis
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