Citation: Zhang Zhaorui, Xu Liang, Tang Hanqin, Wu Boxin, Feng Di, Guo Changbin. Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl₃·7H₂O Catalyzed Groebke-Blackburn-Bienayme Reaction[J]. Chinese Journal of Organic Chemistry, ;2017, 37(5): 1252-1257. doi: 10.6023/cjoc201701024 shu

Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl₃·7H₂O Catalyzed Groebke-Blackburn-Bienayme Reaction

Department of Chemistry, Capital Normal University, Beijing 100048

Corresponding author: Guo Changbin, guocb@cnu.edu.cn
Received Date: 10 January 2017
Revised Date: 12 February 2017

Fund Project: the Program for Excellent Talents of Beijing City 20071D0501600227and the Beijing Municipal Commission of Education KM201010028011Project supported by the National Natural Science Foundation of China 30873140

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A simple, efficient and eco-friendly "one-pot" method for the convenient synthesis of imidazo-fused heterocycles has been developed. The reaction was catalyzed by CeCl₃·7H₂O in ethanol under 60 ℃ via Groebke-Blackburn-Bienayme (GBB) reaction of aldehydes, aminoazines and isocyanides. This method has many advantages of a wide range of substrates, short reaction time and easy purification. In addition, we conducted a comparative study of LaCl₃·7H₂O with CeCl₃·7H₂O on their catalytic effect under the same reaction conditions, and found that CeCl₃·7H₂O was comparable to LaCl₃·7H₂O as catalyst in GBB reaction.
- Groebke-Blackburn-Bienayme reaction,
- imidazo-fused heterocycles,
- CeCl₃·7H₂O,
- LaCl₃·7H₂O,
- Groebke-Blackburn-Bienayme反应
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl3·7H2O Catalyzed Groebke-Blackburn-Bienayme Reaction

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通讯作者: 陈斌, bchen63@163.com

Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl₃·7H₂O Catalyzed Groebke-Blackburn-Bienayme Reaction