Citation: Lu Wenyu, Yu Wenjing, Sun Dequn. Advances in Application of Marine Bioactive Peptides in Drug Development[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1681-1700. doi: 10.6023/cjoc201612062 shu

Advances in Application of Marine Bioactive Peptides in Drug Development

Marine College, Shandong University at Weihai, Weihai 264209

Corresponding author: Sun Dequn, dequn.sun@sdu.edu.cn
Received Date: 26 December 2016
Revised Date: 14 February 2017
Available Online: 31 July 2017

Figures(23)

The ocean is the most resource-rich area on earth. The living environment of marine life is complicated, so that they form a special structure of the active substances. Coupled with the progress of science and technology, people are increasingly concerned about how to find new active substances from marine life, which makes the marine bioactive peptide is widely concerned. Bioactive peptides have a variety of activities, the study shows that these substances have antioxidant, antihypertensive, anti-virus and anti-tumor activity. It has the advantages of low toxicity, high targeting specificity and strong biological activity. At present, some of bioactive peptides extracted from sea cucumbers, conus, ascidians, sponges, marine fungi, molluscs, or analogues derived from these compounds have entered the market or clinical stage. The current research status of marine bioactive peptides is reviewed including their source, synthetic method, chemical structure, activity, mechanism, clinical efficacy and safety. Research prospects in this field are discussed.
- marine peptide,
- bioactivity,
- pharmaceutical,
- clinical trial
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沈阳化工大学材料科学与工程学院沈阳 110142