Citation: Zhang Zhiguo, Zheng Dan, Ma Na'na, Bi Jingjing. Brønsted Acid-Promoted the Synthesis of Furo[2, 3-b]quinolines[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1824-1829. doi: 10.6023/cjoc201612032 shu

Brønsted Acid-Promoted the Synthesis of Furo[2, 3-b]quinolines

School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Corresponding author: Zhang Zhiguo, zhangzg@htu.edu.cn
Received Date: 8 December 2016
Revised Date: 19 January 2017
Available Online: 1 July 2017
Fund Project: the National Natural Science Foundation of China 21272057the Outstanding Young Talent Cultivation Project Funding of Henan Normal University 14YR002the Key Project of Henan Provincal Educational Committee 14B150042the Young Backbone Teachers Fund of Henan Province 2014GGJS-049the National Natural Science Foundation of China 21372065Project supported by the National Natural Science Foundation of China (Nos. 21272057, 21372065), the Young Backbone Teachers Fund of Henan Province(No. 2014GGJS-049), the Key Project of Henan Provincal Educational Committee (Nos. 14A150019, 14B150042, 15A150015), the Science & Technology Innovation Talents in Universities of Henan Province (No. 17HASTIT002), and the Outstanding Young Talent Cultivation Project Funding of Henan Normal University (No. 14YR002)the Science & Technology Innovation Talents in Universities of Henan Province 17HASTIT002the Key Project of Henan Provincal Educational Committee 15A150015the Key Project of Henan Provincal Educational Committee 14A150019

Figures(4)

The furoquinoline unit is present in many natural products. Here, an approach is presented for the preparing of furo[2, 3-b]quinolines from readily available multi-substituted furans in the presence of Brønsted acid via an intramolecular cyclization under the heating conditions. Simple operation, good compatibility, high regioselectivity and morderate yields are the advantages of the method.
- Brønsted acid,
- furo[2, 3-b]quinoline,
- trifluoromethanesulfonic acid,
- Friedel-Crafts reaction
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