Citation: Wang Mengmeng, Zhang Qingqing, Yue Kai, Li Qingshan, Xu Fengbo. Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1774-1780. doi: 10.6023/cjoc201612030 shu

Synthesis and Insecticidal Activity of o-Carboxamidobenzamide Compounds Containing 2-(Substituted phenyl)oxazole Group

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, NanKai University, TianJin 30071

Corresponding author: Li Qingshan, Xu Fengbo,
Received Date: 7 December 2016
Revised Date: 22 February 2017
Available Online: 8 July 2017
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 20772060, 21172114) and the State Key Laboratory of Elemento-Organic Chemistry, Nankai UniversityNational Natural Science Foundation of China 20772060National Natural Science Foundation of China 21172114

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In order to study the insecticidal activity of o-carboxamidobenzamide compounds, to investigate the structure-activity relationships of these compounds, 2-amino-3-hydroxypropionic acid and substituted 2-nitrobenzoic acid were used as starting materials to synthesize 29 diamides target compounds containing 2-substituted phenyloxazole groups, the yields were in the range of 30% and 50%. The insecticidal activities of these compounds were investigated. To some extend, the title compounds showed insecticidal activity against oriental armyworm (Mythimna separata Walker) in vitro. 2-(2-bromophenyl)-N-(4-chloro-2-(methoxy carbamoyl)-6-methyl phenyl) oxazole-4-carbox-amide (compound 11p) showed the highest insecticidal activity among these compounds. The structure-activity relationship of these compounds was summarized and the compounds with high activity were obtained.
- insecticide,
- o-carboxamidobenzamide compounds,
- benzoxazole compounds
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