Citation: Guo Fangjie, He Yuxuan, Wang Jingyun, Sun Jing, Zhou Mingdong. Potassium tert-Butoxide Promoted Formation of Alkyl Aryl Thioethers at Room Temperature: Synthesis and Mechanism[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1556-1559. doi: 10.6023/cjoc201612003 shu

Potassium tert-Butoxide Promoted Formation of Alkyl Aryl Thioethers at Room Temperature: Synthesis and Mechanism

School of Chemistry and Materials Science, Liaoning Shihua University, Fushun 113001

Corresponding author: Sun Jing, sunjing@lnpu.edu.cn Zhou Mingdong, mingdong.zhou@lnpu.edu.cn
Received Date: 2 December 2016
Revised Date: 14 January 2017

Fund Project: the Fushun Science & Technology Program FSKJHT201423the National Natural Science Foundation of China 21101085the Natural Science Foundation of Liaoning Province 2015020196the Liaoning Excellent Talents Program in University LJQ2012031the Talent Scientific Research Fund of Liaoning Shihua University 2016XJJ-006

The C—S cross-coupling of aryl halides with alkyl thiols under transition metal-free conditions was investigated. Good to excellent yields can be obtained for a variety of electron-poor aryl halides with alkyl thiols in the presence of KO^tBu even at room temperature. The mechanisms for transition metal-free coupling reactions are discussed.
- C—S cross-coupling,
- aryl halides,
- mechanism,
- alkyl aryl thioethers
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