Citation: Meng Xiangde, Zhou Sha, Xie Yongtao, Zhao Yu, Xiong Lixia, Zhou Sha, Li Zhengming. Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(4): 908-913. doi: 10.6023/cjoc201610027 shu

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: Zhou Sha, mengsha171657@163.com Li Zhengming, nkzml@vip.163.com
Received Date: 17 October 2016
Revised Date: 11 December 2016

Fund Project: the National Natural Science Foundation of China 21602118

Figures(3)

In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid diamide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity relationship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.
- pyridine,
- phthalic acid diamides,
- synthesis,
- insecticidal activity,
- dual-chiral
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