Citation: Sun Guoshao, Wang Lingna, Jin Shuhui, Dong Yanhong, Lu Huizhe, Zhang Jianjun. Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl[J]. Chinese Journal of Organic Chemistry, ;2017, 37(1): 157-165. doi: 10.6023/cjoc201608006 shu

Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl

China Agricultural University, Beijing 100193

Corresponding author: Jin Shuhui, shuhuij@cau.edu.cn Zhang Jianjun, zhangjianjun@cau.edu.cn
Received Date: 10 August 2016
Revised Date: 31 August 2016

Fund Project: the National Natural Science Fondation of China 21337005National Science Foundation for Fostering Talents in Basic Research of China J1210064

Figures(3)

Based on benalaxyl pesticide metabolite structure framework, fourteen novel diamide derivatives were synthesized by the reaction of amine and N₂-carboxyacetyl-N₁-(2, 6-dimethylphenyl) alanine methyl ester.Their structures were identified by ¹H NMR, ¹³C NMR spectra and HRMS.The results of bioassay indicated that some compounds possess potential fungicidal activities against 8 kinds of bacteria, and the antibacterial activity of some compounds was better than that of benalaxyl.At a dosage of 5.0×10^-5 g/mL, compound 7d displayed 94.2% antifungal activities against Rhizoctonia solani.Compound 8f displayed 87.1% and 88.9% antifungal activities against Phytophthora capsici and Rhizoctonia solani.
- benalaxyl,
- metabolite,
- diamide,
- synthesis,
- antifungal activity
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