Citation: Xie Zongbo, Zhang Shiguo, Jiang Guofang, Liang Meng, Le Zhanggao. Pepsin-Catalyzed Synthesis of 2, 3-Dihydroquinazolin-4(1H)-one Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(2): 514-519. doi: 10.6023/cjoc201606030 shu

Pepsin-Catalyzed Synthesis of 2, 3-Dihydroquinazolin-4(1H)-one Derivatives

Xie Zongbo ^a,b ,
Zhang Shiguo ^b ,
Jiang Guofang ^b,*,, ,
Liang Meng ^b ,
Le Zhanggao ^a,b,*,,

a.
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013
b.
Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Jiang Guofang, gfjiang@ecit.cn Le Zhanggao, zhgle@ecit.cn
Received Date: 20 June 2016
Revised Date: 17 September 2016

Fund Project: the National Natural Science Foundation of China 21462001the Program for Changjiang Scholars and Innovative Research Team in University IRT13054the Natural Science Foundation of Jiangxi Province 20142BAB203008the National Natural Science Foundation of China 21465002

The catalytic property of some hydrolases for the cyclocondensation of aldehydes with 2-aminobenzamide was researched in alcohol solvent, and pepsin was selected as the best catalyst. The reaction conditions were optimized through investigating the temperature, the enzyme loading, the ratio of substrates and the reaction time. Under the optimal conditions, 5 mg of pepsin could catalyze the cyclizing reaction of aldehydes with 2-aminobenzamide, and the corresponding 2, 3-dihydroquinazolin-4(1H)-ones were successfully obtained in high yields.
- 2-aminobenzamide,
- aldehyde,
- cyclocondensation,
- 2, 3-dihydroquinazolin-4(1H)-ones,
- pepsin
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