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Citation: Wang Lei, Liang Yuxia, Zhang Bao, Feng Yaqing. Blaise Reaction Co-catalyzed by I₂ and Cu⁺[J]. Chinese Journal of Organic Chemistry, ;2017, 37(1): 209-212. doi: 10.6023/cjoc201604045 shu

Blaise Reaction Co-catalyzed by I₂ and Cu⁺

Wang Lei ^a,b ,
Liang Yuxia ^a,b ,
Zhang Bao ^a,c,*,, ,
Feng Yaqing ^a,b,c

a.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072
b.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072
c.
Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin 300072

Corresponding author: Zhang Bao, baozhang@tju.edu.cn
Received Date: 21 April 2016
Revised Date: 7 July 2016

Fund Project: the Innovation Platform Program of Tianjin Science and Technology 14TXGCCX00017

Figures(4)

The yield of Blaise reaction of trimethylsilyl protected (S)-4-chloro-3-hydroxyl but yronitrile with tert-butyl bromo zinc acetate is improved nearly 20% by using Cu⁺ or I₂ as a single catalyst.Interestingly, when Cu⁺ and I₂ were used as the co-catalyst, the reaction yield was further improved from 72.1% to 97.0%.These results, which were reasonably explained via the reaction mechanism, not only indicate that the Blaise reaction can be applied more widely, but also provide a simple route for the preparation of the side chain of rosuvastatin and atorvastatin.Moreover, this optimized Blaise reaction provides a new insight into the C-C bond formation.
- Blaise reaction,
- catalyst,
- side chain of rosuvastatin
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Blaise Reaction Co-catalyzed by I2 and Cu+

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Blaise Reaction Co-catalyzed by I₂ and Cu⁺