Citation: Zhou Junjie, Tang Zhike, Zhang Chao, Wang Dongtian, Zhang Kai, Sun Hongbin. CuCN^-TsOH Catalyzed Synthesis of 2-Aryl-4, 5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor[J]. Chinese Journal of Organic Chemistry, ;2016, 36(11): 2662-2669. doi: 10.6023/cjoc201604038 shu

CuCN^-TsOH Catalyzed Synthesis of 2-Aryl-4, 5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor

1.
Department of Chemistry, Northeastern University, Shenyang 110819

Corresponding author: Sun Hongbin, sunhb@mail.neu.edu.cn
Received Date: 18 April 2016
Revised Date: 19 June 2016

Figures(5)

2-Imidazolines were synthesized via CuCN^-TsOH catalyzed cyclization of nitriles with ethylenediamine in a continuous-flow microreactor. The CuCN^-TsOH dissolves in ethylenediamine homogeneously and is a suitable catalyst for the continuous reactions. Under the flow condition, the 2-imidazolines were obtained with high yields in 5 min for most substrates. The "in-tube retention time gradient" (IT-RTG) is achieved in the continuous-flow microreactor, and it is applied in monitoring the reaction progress.
- continuous-flow microreactor,
- 2-imidazoline,
- catalysis,
- cuprous cyanide,
- nitrile,
- cyclization
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

CuCN-TsOH Catalyzed Synthesis of 2-Aryl-4, 5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor

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通讯作者: 陈斌, bchen63@163.com

CuCN^-TsOH Catalyzed Synthesis of 2-Aryl-4, 5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor