Citation: Hu Dongyan, Li Mengsun. Copper-Catalyzed Coupling of Alkynes and Amines for the Synthesis of Propargyl Amines in the Presence of PhI(OAc)₂[J]. Chinese Journal of Organic Chemistry, ;2016, 36(8): 1926-1931. doi: 10.6023/cjoc201603003 shu

Copper-Catalyzed Coupling of Alkynes and Amines for the Synthesis of Propargyl Amines in the Presence of PhI(OAc)₂

Hu Dongyan ^a,b,*,, ,
Li Mengsun ^a,b

a.
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
b.
University of the Chinese Academy of Sciences, Beijing 100049

Corresponding author: Hu Dongyan, hudy@cib.ac.cn
Received Date: 3 March 2016
Revised Date: 11 April 2016

Figures(2)

In the presence of iodobenzene diacetate (PhI(OAc)₂), a new CuBr catalyzed coupling reaction of alkynes and amines for the synthesis of propargyl amines was developed. When terminal alkynes, PhI(OAc)₂, and amines were reacted in CH₃CN at 70 ℃ for 3 h under N₂ atmosphere and in the presence of CuBr, the desired propargyl amines were obtained in good yields. Furthermore, no matter aromatic or aliphatic alkynes, were all found to tolerate the reaction conditions. To the best of our knowledge, it is the first time that PhI(OAc)₂ has been used for the synthesis of propargyl amines in one-pot operation from alkynes and amines.
- cuprous bromide,
- PhI(OAc)₂,
- propargyl amines
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Copper-Catalyzed Coupling of Alkynes and Amines for the Synthesis of Propargyl Amines in the Presence of PhI(OAc)2

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Copper-Catalyzed Coupling of Alkynes and Amines for the Synthesis of Propargyl Amines in the Presence of PhI(OAc)₂