Citation: Wu Jing, Kong Hanhan, Ding Mingwu. Synthesis of 12H, 14H-Quinazolino[3, 4-a]-3, 1-benzoxazines[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1662-1667. doi: 10.6023/cjoc201601026 shu

Synthesis of 12H, 14H-Quinazolino[3, 4-a]-3, 1-benzoxazines

1.
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079

Corresponding author: Ding Mingwu, mwding@mail.ccnu.edu.cn
Received Date: 20 January 2016
Revised Date: 29 February 2016

Fund Project: the National Natural Science Foundation of China 21572075

Figures(4)

A one-pot synthetic approach to new fused heterocyclic skeleton 12H, 14H-quinazolino[3, 4-a]-3, 1-benzoxazine by Staudinger/aza-Wittig sequence has been developed. The sequential reaction of azides 3 with triphenylphosphine and acyl chlorides or CS₂ produced 12H, 14H-quinazolino[3, 4-a]-3, 1-benzoxazines 5 or 6 in good yields via a consecutive Staudinger/ aza-Wittig/ cyclization reaction.
- benzoxazine,
- quinazoline,
- quinazolinobenzoxazine,
- aza-Wittig reaction,
- azide
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沈阳化工大学材料科学与工程学院沈阳 110142