Citation: Shen Wei, Wang Lin, Chen Min, Wu Min, Bao Xiaofeng. A Highly Selective and Sensitive Pyrene Derivative 1-(Pyren-1-yl)-N, N-bis(pyridin-2-ylmethyl)methanamine Chemosensor for Zinc(Ⅱ) in the Presence of Pyrophosphatic Acid[J]. Chinese Journal of Organic Chemistry, ;2016, 36(9): 2204-2211. doi: 10.6023/cjoc201601018 shu

A Highly Selective and Sensitive Pyrene Derivative 1-(Pyren-1-yl)-N, N-bis(pyridin-2-ylmethyl)methanamine Chemosensor for Zinc(Ⅱ) in the Presence of Pyrophosphatic Acid

Shen Wei ^a,*,, ,
Wang Lin ^b ,
Chen Min ^a ,
Wu Min ^c ,
Bao Xiaofeng ^d,*,,

a.
Jiangsu Key Laboratory of Pesticide Science, Department of Science, Nanjing Agricultural university, Nanjing 210095
b.
School of Biology and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
c.
School of Life Science & Technology, Chin1 Pharmacutical University, Nanjing 210009
d.
Department of Biochemical Engineering, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: Shen Wei, swgdj@njau.edu.cn Bao Xiaofeng,
Received Date: 14 January 2016
Revised Date: 27 April 2016

Fund Project: the National Natural Science Foundation of China 21302098the Fundamental Research Funds for the Central Universities KJQN201415

Figures(14)

A pyrene derivative PYPA, namely, 1-(pyren-1-yl)-N, N-bis(pyridin-2-ylmethyl)methanamine (PYPA), was synthesized to develop a chemosensor. The studies show that PYPA exhibits high sensitivity and selectivity toward Zn²⁺ over many other metal cations in the presence of pyrophosphatic acid (PPi). It has a low detection limit of 0.030 nmol/L. Detection of Zn²⁺ was not interfered by various cations or anions. In the presence of PPi, over a 8-fold fluorescence enhancement at 383 nm was observed within 20 s. Cell studies further demonstrated that PYPA can be a potential probe to detect Zn²⁺ in human liver cells (L-02).
- pyrene derivative,
- Zn²⁺ fluorenscent probe,
- living cell image
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