Citation: Li Gongming, Sun Dequn. Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods[J]. Chinese Journal of Organic Chemistry, ;2016, 36(8): 1715-1740. doi: 10.6023/cjoc201601009 shu

Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods

Li Gongming ,
Sun Dequn ^*,,

1.
Marine College, Shandong University at Weihai, Weihai 264209

Corresponding author: Sun Dequn, dequn.sun@sdu.edu.cn
Received Date: 9 January 2016
Revised Date: 16 February 2016

Figures(48)

Fluorine-containing groups have strong electron-withdrawing effect and high lipophilicity, organic molecules incorporated fluorine-containing groups can improve its function. Therefore, the incorporation of fluorine-containing groups into molecules has become the current research hotspot. The method for incorporation of CF₃S group becomes one of the hot research field due to its excellent nature. The strategy for incorporation of CF₃Se, CF₃O and CF₃CH₂O groups has also been the attention of researchers. ¹⁸F has nearly ideal nuclear properties and is the most widely used positron emission tomography (PET) radioisotope for clinical imaging. Therefore, the development of new [¹⁸F]radiotracers becomes the research focus of many researchers. The method for ¹⁸F-labeling of biomolecules is the key to the development of new [¹⁸F]radiotracers. This paper mainly introduce the recently reported methodology of direct incorporating CF₃X (X＝S, Se, O, CH₂O) groups into molecules and some research results of ¹⁸F-labeling methods. Furthermore, some noteworthy research directions in this field are summarized.
- trifluoromethylthiolation,
- trifluoromethylselenolation,
- trifluoromethyloxylation,
- trifluoroethoxylation,
- ¹⁸F-labeling
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沈阳化工大学材料科学与工程学院沈阳 110142

Recent Advances of Direct Incorporation of Fluorine-Containing Groups and 18F-Labeling Methods

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通讯作者: 陈斌, bchen63@163.com

Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods