Citation: Gao Yanian, Zhang Mengye, Qian Haiyan, Xie Qianwen, Chen Ming, Xu Shuangshuang, Rong Liangce. A Rapid and Green Synthesis of 8-Aryl-5, 7, 7-tricyanoisoquinoline Derivatives at Room Temperature under Solvent-Free and Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1706-1711. doi: 10.6023/cjoc201512025 shu

A Rapid and Green Synthesis of 8-Aryl-5, 7, 7-tricyanoisoquinoline Derivatives at Room Temperature under Solvent-Free and Catalyst-Free Conditions

1.
School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Corresponding author: Rong Liangce,
Received Date: 20 December 2015
Revised Date: 25 February 2016

Fund Project: the National Natural Science Foundation of China No. 21571087

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A facile and rapid synthesis of 8-aryl-5, 7, 7-tricyanoisoquinoline derivatives from the reaction of aromatic aldehydes, malononitrile, and N-substituted-4-piperidones at room temperature under solvent-free and catalyst-free conditions. The N-ethylpiperidin-4-one was first used for the synthesis of 6-amino-2-ethyl-8-aryl-2, 3, 8, 8a-tetrahydroisoquinoline-5, 7, 7(1H)-tricarbonitrile derivatives. This method offers several advantages in terms of its mild conditions, available raw materials, simple operation, high yields, short reaction time and green process. The products were identified by IR, ¹H NMR and HRMS. The reported method is the efficient approach for the synthesis of isoquinoline derivatives.
- isoquinoline,
- N-ethylpiperidin-4-one,
- ethyl 4-oxopiperidine-N-carboxylate,
- green synthesis
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