Citation: Yan Haohao, Zhao Boliang, Gao Yu, Du Daming. Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1643-1652. doi: 10.6023/cjoc201512021 shu

Facile Synthesis of (2-Amino-3-(benzothiazol-2-yl)-4H-chromen- 4-yl)phosphonate Derivatives under Mild Conditions

1.
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081

Corresponding author: Du Daming, dudm@bit.edu.cn
Received Date: 15 December 2015
Revised Date: 22 January 2016

Fund Project: the National Natural Science Foundation of China No. 21272024

Figures(3)

A series of (2-amino-3-(benzothiazol-2-yl)-4H-chromen-4-yl)phosphonate derivatives were synthesized in good to excellent yields by Michael addition/cyclization of diphenyl phosphite to diverse substituted(E)-2-(benzothiazol-2-yl)-3-(2-hydroxyphenyl)acrylonitriles under catalyst-free condition in water. Meanwhile, one-pot three component reaction of salicylaldehyde, 2-(benzothiazol-2-yl)acetonitrile and diphenyl phosphate was also tested using Et₃N as catalyst to synthesize these phosphonate derivatives
- Michael addition,
- cyclization,
- phosphonate,
- chromene,
- heterocycle
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