Citation: Zhang Zhaorui, Zheng Xiaolin, Guo Changbin. Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1241-1265. doi: 10.6023/cjoc201511004 shu

Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles

1.
Department of Chemistry, Capital Normal University, Beijing 100048

Corresponding author: Guo Changbin, guocb@cnu.edu.cn
Received Date: 3 November 2015
Revised Date: 7 January 2016

Fund Project: and the Beijing Municipal Commission of Education No.KM201010028011Project supported by the National Natural Science Foundation of China No.30873140the Program for Excellent Talents of Beijing City No.20071D0501600227

Figures(61)

Ugi/de-Boc/cyclization (UDC) strategy represents a “three-step, one-pot procedure”, employing the Ugi multi-component reaction utilizing one bi-functional group substrates with N-Boc-protected amino, followed by Boc-deprotection and cyclization to synthesize nitrogen-containing heterocycles. This strategy has the characteristics of rapid, efficiency, economy and structural diversity, which can be used to build libraries of complex nitrogen-containing heterocycles and has drawn much attention recently. In this paper, the research progress of UDC strategy in the synthesis of five-, six- and seven-mem- bered heterocycles and natural products were summarized.
- UDC,
- Ugi reaction,
- de-Boc group,
- cyclization,
- nitrogen-containing heterocycle,
- synthesis,
- multi-component reaction
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