Citation: Jia Wan, Zhao Lizhi, Wei Hengxu, Zhu Lindong, Fu Lei, Chen Weichun. Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent[J]. Chinese Journal of Organic Chemistry, ;2016, 36(5): 1060-1064. doi: 10.6023/cjoc201510031 shu

Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent

Jia Wan ^a ,
Zhao Lizhi ^b ,
Wei Hengxu ^b ,
Zhu Lindong ^b ,
Fu Lei ^a ,
Chen Weichun ^b,*,,

a.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240
b.
Research and Developemnt Center in Shanghai of GlaxoSmithKline, Shanghai 201203

Corresponding author: Chen Weichun, weichun.w.chen@gsk.com
Received Date: 26 October 2015
Revised Date: 16 December 2015

A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.
- iron-catalyzed,
- secondary alkyl choloride,
- alkynes Grignard reagents,
- cross-coupling reactions,
- green chemistry
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