Citation: Li Zhipeng, Chen Feiran, Wang Dongyang, Huang Xingtian, Li Yiqun. Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(4): 838-843. doi: 10.6023/cjoc201510010 shu

Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives

1.
Department of Chemistry, Jinan University, Guangzhou 510632

Corresponding author: Li Yiqun,
Received Date: 11 October 2015
Available Online: 25 November 2015
Fund Project: 国家自然科学基金(Nos.21372099,21072077) (Nos.21372099,21072077)广东省自然科学基金(No.10151063201000051,8151063201000016)资助项目. (No.10151063201000051,8151063201000016)

An efficient method for the synthesis of benzopyran derivatives and pyrano[2,3-c]pyrazole derivatives via multicomponent reaction in the presence of agarose hydrogel entrapped trisodium citrate (gel-citrate) as catalyst is developed. The protocol presented here has the merits of easy preparation and handling of catalyst, environmentally benign, simple operation and convenient workup, and excellent yields. Moreover, the catalyst could be recovered and reused at least 6 cycles without apparently losing its activities.
- agarose,
- hydrogel-entrapped catalyst,
- benzopyran,
- pyrano[2,3-c]pyrazole,
- multicomponent reaction
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